This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.

Tripeptide-29 200mg (Collagen peptide)

Tripeptide-29 is a synthetic mimic of one of the basic building blocks of collagen. Collagen is a long-chain polymer made of short monomeric repeats that are generally made up of three amino acids in sequence. These repeats bond together to create secondary structures, which then combine to form tertiary and even quaternary structures. These complex structures have many emergent properties that the peptide subunits don’t possess. However, changing the nature of the peptide subunits can change the ultimate properties of a quaternary collage compound. Collagen subunits almost always follow the pattern of Gly-Pro-X or Gly-X-Hyp. Tripeptide-29 is a Gly-Pro-Hyp peptide, making it a perfect synthetic analogue of common collage building blocks.

Tripeptide-29 Peptide

Chemical Formula: C12H19N3O5

Molecular Weight: 285.3 g/mol

Amino Acid Sequence: Gly-Pro-Hyp

What Is Tripeptide-29?

Tripeptide-29 is a synthetic analogue of a collage building block. The three-amino-acid long peptide mimics the common Gly-Pro-X/Gly-X-Hyp format of collagen subunits.

What Does Tripeptide-29 Do?

Fundamentally, tripeptide-29 acts as a building block of larger collagen molecules. In so doing, it can change, by virtue of its amino acid sequence and relative frequency with the collagen superstructure, the tertiary and quaternary properties of a collagen molecule. It is important to remember that collagen is not just a structural protein, but also plays roles in cell adhesion, tissue regulation, and healing. Thus, tripeptide-29 has the potential to impact a multitude of physiologic features.

The Roles of Collagen

To be clear, collagen is one of the most ubiquitous molecules in the animal kingdom. It is found in humans, all mammals, reptiles, fish, birds, and even algae. Collage plays roles in:

Tripeptide-29 Research

In vitro research into tripeptide-29 has revealed that the peptide, in its non-polymerized form, is a partial agonists of the collagen receptor GPVI[1]. GPVI is expressed on the surface of platelets, the cell-like structures responsible for the early formation of blood clots. The GPVI receptor plays a crucial role in the collagen-induced activation of platelet aggregation in vascular tissue, a first step to clot formation and tissue repair. Thus, collagen fibers are generally considered thrombogenic.

When dysregulated, collagen thrombogenesis may lead to the development of blood clots. Interestingly, crosslinking of tripeptide-29 appears to boost GPVI activation, suggesting that the peptide could be useful in understanding how to create a “just-right” clotting environment in the setting of various bleeding/clotting disorders.

Tripeptide-29 and Collagen Stability

Benchtop research into the role of short peptides like tripeptide-29 has revealed that they can be used to modulate the stability of collagen. Tripeptide-29, in particular, has helped scientists to understand that the ultimate structure of collagen is influenced most by the last peptide in a tripeptide monomer. In a monomer of A-B-C, it is the peptide in the C position that has most influence on final collagen stability[2]. This finding could help scientists to one day create synthetic implants for cartilage, bone, teeth, and more.

Collagen and Free Radical Damage

Free radical damage is the primary cause of cellular and tissue aging. The body has a number of defenses against free radical damage, but they all become less effective over time. Research in sea cucumber has revealed that collagen hydrolysates constructed from monomers like tripeptide-29 are effective radical scavengers, and that the structure of the tripeptide monomer can affect scavenger activity. No research has been carried out on Tripeptide 29, yet, but there is interest in determining how such peptides could be used in foods and nutraceutical products[3].

Tripeptide-29 Regulates Tissue Fibrosis

In vitro studies of pig skin, cattle skin, fish scales, and chick feet have revealed that tripeptide-29 is an inhibitor of dipeptidylpeptidase-IV activity[4], [5]. Dipeptidylpeptidase-IV (DPP4) is an enzyme found mostly in cells associated with immune signaling and cell apoptosis. It is an intrinsic part of the cell membrane and indiscriminately destroys growth factors, chemokines, neuropeptides, and vasoactive peptides. It also plays a large role in glucose metabolism by breaking down incretins, hormones that stimulate a decrease in blood glucose levels.

Animal studies have revealed that DPP4 plays a role in the development of fibrosis in organs that include the kidney and liver[5]. Inhibiting the enzyme thus prevents scarring in disease processes that affect these organs. Tripeptide-29 maybe doubly beneficial in this setting, as diabetes is a prime cause of kidney fibrosis. The ability of Tripeptide-29 to stimulate glucose uptake and reduce fibrosis, both by inhibiting DPP4, opens a number of research avenues in the control of not just diabetes, but its pathologic sequelae as well.

Tripeptide-29 and Skin Tone

There is recent interest in the role of tripeptide-29 and other tripeptides in protecting skin against the normal process of aging. Research in animals suggests that topical use of tripeptides can reduce the visible effects of skin aging by improving contour, reducing skin deformation, and boosting hydration. There is also evidence that tripeptides can smooth skin texture and reduce the appearance of brown and red spots. In fact, 90% of subjects in the study showed improved moisturization of the skin in addition to increased flexibility secondary to improve elasticity[6].

When combined with certain hexapeptides, topical tripeptide-29 can boost skin turnover and reduce fine lines, crow’s feet, under eye bags, and eye hollowing. In these animal studies, roughly 50% of subjects showed improved skin appearance with twice daily application of the peptide paste[7].

Referenced Citations

Tripeptide-29 is a synthetic collagen-like tripeptide composed of Hydroxyproline, Proline, Glycine. CAS No. 2239-67-0 Water Content: <5% Sequence: Gly-Pro-Hyp Molecular Formula: C12H19N3O5 Molecular Weight: 285.3

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body.  These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease.  Bodily introduction of any kind into humans or animals is strictly forbidden by law.

Tripeptide-29 is a synthetic collagen-mimetic peptide composed of the amino acid sequence Gly-Pro-Hyp (Glycine-Proline-Hydroxyproline). As one of the fundamental structural motifs found throughout collagen, Tripeptide-29 has become an important research tool in studies involving collagen biology, tissue engineering, extracellular matrix function, skin aging, wound repair, fibrosis regulation, and biomaterials development.

As interest in collagen-related research continues to expand, researchers frequently compare Tripeptide-29 vendors based on purity, analytical testing, pricing, product documentation, and supplier transparency.

This Tripeptide-29 Vendor Price Comparison Guide helps researchers evaluate suppliers using objective criteria, including:

• Product Pricing

• Cost Per Milligram

• Product Purity

• Third-Party Testing

• Certificate of Analysis (COA)

• Vendor Reputation

• Customer Reviews

• Shipping Performance

• Product Availability

• Overall Value

Whether you're seeking the lowest-priced Tripeptide-29 supplier, vendors with comprehensive analytical testing, or the highest-purity collagen peptides available, this guide provides a framework for comparing research suppliers.

Explore Tripeptide-29 Vendors by Criteria

Most Popular Tripeptide-29 Vendors

Compare suppliers frequently selected by collagen, skin biology, and tissue-engineering researchers.

Highest Reviewed Tripeptide-29 Vendors

Discover vendors with strong customer feedback and positive marketplace reputations.

Lowest Price Tripeptide-29 Vendors

Identify suppliers offering competitive pricing and attractive cost-per-milligram value.

Highest Purity Tripeptide-29 Vendors

Review suppliers providing detailed purity verification and analytical documentation.

Best Value Tripeptide-29 Vendors

Compare pricing, testing standards, product quality, and customer support to determine overall value.

Fastest Shipping Tripeptide-29 Vendors

Evaluate fulfillment speed, packaging quality, and delivery reliability.

Newly Listed Tripeptide-29 Vendors

Explore recently added suppliers offering Tripeptide-29 research products.

What Is Tripeptide-29?

Overview

Tripeptide-29 is a synthetic analogue of a common collagen building block consisting of:

Glycine – Proline – Hydroxyproline (Gly-Pro-Hyp)

This sequence closely mirrors one of the repeating structural motifs frequently observed throughout collagen molecules.

Researchers investigate Tripeptide-29 because collagen plays essential roles in:

• Structural support

• Tissue integrity

• Cell adhesion

• Extracellular matrix biology

• Tissue repair

• Wound healing

• Skin function

• Connective tissue maintenance

As a result, Tripeptide-29 serves as a useful model for studying collagen assembly and function.

Molecular Characteristics

Peptide Information

Researchers evaluating Tripeptide-29 should carefully review product specifications and analytical documentation.

Peptide Name

Tripeptide-29

Alternative Name

Collagen Peptide Mimetic

Amino Acid Sequence

Gly-Pro-Hyp

Molecular Formula

C12H19N3O5

Molecular Weight

285.3 g/mol

CAS Number

2239-67-0

Classification

Synthetic Collagen-Mimetic Peptide

Research Category

Collagen & Extracellular Matrix Research

Why Researchers Compare Tripeptide-29 Vendors

Research outcomes often depend on peptide quality and consistency.

Supplier differences may include:

• Peptide purity

• Manufacturing standards

• Batch consistency

• Stability testing

• Storage procedures

• Product documentation

• Shipping reliability

• Quality-control practices

Comparing suppliers solely on price may overlook important quality factors.

How We Compare Tripeptide-29 Vendors

Third-Party Laboratory Testing

Independent laboratory verification remains one of the strongest indicators of product quality.

Researchers should prioritize suppliers offering:

• Third-party testing

• Identity verification

• Purity analysis

• Batch-specific results

Certificate of Analysis (COA)

A quality COA should include:

• Lot number

• Purity percentage

• Test date

• Identity confirmation

• Analytical methodology

Product Purity

Purity is one of the most important criteria for collagen-related research.

Higher-purity preparations generally support greater experimental consistency.

Cost Per Milligram

Comparing vial prices alone can create misleading conclusions.

Cost Per Milligram Formula

Product Price ÷ Total Milligrams = Cost Per Milligram

This provides a more accurate comparison of product value.

Customer Reviews

Customer experiences may provide insight regarding:

• Product consistency

• Shipping reliability

• Packaging quality

• Customer support

• Purchasing experience

Vendor Reputation

Established peptide suppliers often demonstrate:

• Consistent quality standards

• Strong testing practices

• Reliable inventory

• Transparent business operations

Current Research & Evidence

Collagen Biology Research

Tripeptide-29 is primarily investigated for its role as a collagen-mimetic peptide.

Researchers use Tripeptide-29 to better understand:

• Collagen assembly

• Collagen stability

• Extracellular matrix formation

• Protein folding mechanisms

These investigations may ultimately assist in the development of advanced biomaterials and tissue-engineering technologies.

Platelet & GPVI Research

Laboratory research suggests Tripeptide-29 may interact with GPVI (glycoprotein VI), a receptor involved in platelet activation and collagen-mediated signaling.

Scientists continue studying these interactions to better understand:

• Platelet biology

• Tissue repair mechanisms

• Vascular signaling

• Clot formation pathways

Tissue Engineering Research

Tripeptide-29 has become increasingly relevant in studies involving:

• Synthetic biomaterials

• Tissue scaffolds

• Cartilage engineering

• Bone regeneration research

• Connective tissue development

Researchers continue exploring how collagen-like peptides influence structural properties of engineered tissues.

Key Findings on Tripeptide-29 Research

Collagen Stability Research

One important area of investigation focuses on collagen stability.

Research suggests that the composition and sequence of collagen subunits can influence:

• Structural integrity

• Thermal stability

• Mechanical properties

• Long-term durability

Tripeptide-29 serves as a useful model for investigating these characteristics.

Extracellular Matrix Research

The extracellular matrix (ECM) plays a critical role in tissue architecture and cellular communication.

Researchers continue studying how collagen-based peptides contribute to:

• Cell signaling

• Tissue organization

• Matrix remodeling

• Wound-repair pathways

Fibrosis Research

Experimental evidence suggests collagen-like peptides may influence pathways related to fibrosis and tissue remodeling.

Researchers have explored relationships involving:

• Dipeptidyl Peptidase-4 (DPP4)

• Fibrotic signaling

• Scar formation

• Connective tissue regulation

This remains an active area of investigation.

Metabolic Research

Because DPP4 participates in glucose regulation pathways, researchers continue exploring whether collagen-derived peptides may influence:

• Glucose metabolism

• Metabolic signaling

• Tissue remodeling in diabetes

• Fibrosis-related disease processes

Further research remains necessary.

Free Radical & Oxidative Stress Research

Investigators have studied collagen hydrolysates and peptide fragments for their potential interactions with oxidative-stress pathways.

Current research focuses on:

• Free-radical biology

• Oxidative damage

• Tissue aging

• Structural protein preservation

Skin Aging Research

Tripeptide-29 has attracted significant interest in cosmetic and skin-science research.

Investigations have explored relationships with:

• Skin elasticity

• Hydration

• Texture

• Fine lines

• Skin appearance

Researchers continue evaluating mechanisms responsible for these observations.

Research Limitations

Most findings concerning Tripeptide-29 originate from:

• In vitro research

• Benchtop experiments

• Cell culture studies

• Early-stage preclinical investigations

Results should not be interpreted as evidence of approved therapeutic applications in humans.

Additional research remains necessary to fully characterize the biological effects of Tripeptide-29.

Product Quality & Analytical Testing

Why Testing Matters

Research-grade Tripeptide-29 should undergo testing to verify:

• Identity

• Purity

• Stability

• Potency

• Batch consistency

Common Testing Methods

High-Performance Liquid Chromatography (HPLC)

Used to evaluate peptide purity and identify impurities.

Mass Spectrometry (MS)

Used to verify molecular identity and molecular weight.

Identity Verification Testing

Confirms peptide composition and sequence.

Stability Testing

Evaluates peptide integrity during storage.

Batch Consistency Testing

Measures consistency across manufacturing lots.

Understanding Tripeptide-29 Pricing

Several factors influence supplier pricing.

Product Purity

Higher-purity peptides often command premium pricing.

Analytical Verification

Comprehensive testing programs increase transparency and quality assurance.

Manufacturing Standards

Stricter quality-control procedures generally increase cost.

Product Format

Pricing may vary depending on:

• Lyophilized powder

• Bulk powder

• Cosmetic-grade formulations

• Research-grade formulations

Vendor Reputation

Trusted suppliers frequently charge premiums due to established quality systems.

Tripeptide-29 Vendor Evaluation Checklist

Quality Verification

✅ Third-party testing available

✅ Certificate of Analysis provided

✅ Identity verification documented

✅ Purity information disclosed

✅ Batch-specific testing available

Vendor Reliability

✅ Positive customer reviews

✅ Transparent business information

✅ Responsive customer support

✅ Reliable inventory availability

Purchasing Experience

✅ Secure checkout process

✅ Tracking available

✅ Clear refund policy

✅ Reliable fulfillment

Red Flags When Comparing Vendors

Testing Concerns

❌ No third-party testing

❌ Missing Certificates of Analysis

❌ Outdated purity reports

❌ Unverified product claims

Transparency Concerns

❌ Hidden specifications

❌ Missing batch numbers

❌ Limited documentation

❌ No company contact information

Service Concerns

❌ Frequent stock shortages

❌ Poor customer communication

❌ Negative customer reviews

❌ Unclear shipping policies

How to Choose the Best Tripeptide-29 Vendor

Prioritize Transparency

Choose suppliers that provide third-party testing and detailed Certificates of Analysis.

Compare Overall Value

Evaluate purity, testing standards, customer support, and pricing together.

Review Documentation

Verify laboratory reports before purchasing.

Consider Vendor Reputation

Established suppliers often offer greater consistency and stronger quality-control programs.

Match Products to Research Needs

Select products and suppliers appropriate for your laboratory requirements and research objectives.

Frequently Asked Questions

What is Tripeptide-29?

Tripeptide-29 is a synthetic collagen-mimetic peptide composed of Glycine-Proline-Hydroxyproline (Gly-Pro-Hyp).

What is Tripeptide-29 used for in research?

Researchers investigate Tripeptide-29 in studies involving collagen biology, extracellular matrix function, tissue engineering, fibrosis, skin aging, and connective tissue research.

Why compare Tripeptide-29 vendors?

Purity, analytical testing, product quality, documentation, and pricing can vary significantly between suppliers.

What should researchers review before purchasing?

Researchers should evaluate:

• Certificate of Analysis

• Purity testing

• Third-party verification

• Identity confirmation

• Vendor reputation

• Customer reviews

Why is third-party testing important?

Independent testing helps verify product identity, purity, and consistency.

Is the cheapest vendor always the best option?

No. Product quality, analytical verification, transparency, and supplier reliability are often more important than price alone.

How often should vendor comparisons be updated?

Pricing, product availability, testing standards, and supplier policies can change frequently and should be reviewed regularly.

Final Thoughts

Tripeptide-29 remains an important research tool in collagen science because it closely mimics one of the fundamental structural units found throughout collagen. Researchers continue studying its role in collagen stability, extracellular matrix biology, fibrosis regulation, tissue engineering, skin aging, and regenerative medicine.

When comparing Tripeptide-29 vendors, researchers should prioritize purity verification, third-party testing, COA availability, supplier reputation, and overall value. A structured vendor-comparison approach can help identify suppliers that meet rigorous research-quality standards.