Research Use Only. This compound is not intended for human consumption or therapeutic use.

Peptide

Where to Buy PNC-27: Vendor Comparison & Research Info

PNC-27 is a synthetic anti-cancer peptide that binds HDM-2 and thus prevents its interaction with the p53 tumor suppressor protein. Research shows that it selectively kills cancer cells by inducing membranolysis (destruction of the cell membrane).

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Lowest Price:$19.99
PNC-27

What is PNC-27?

What is PNC-27?

PNC-27 is a synthetically created peptide designed to specifically target and destroy cancer cells. It is a member of the PNC set of investigational proteins designed to attach to malformed (cancerous) cells and cause them to die through cell necrosis, all while leaving normal, healthy cells intact and unharmed.

The PNC-27 peptide contains an HDM-2 binding domain corresponding to residues 12-26 of p53 and a transmembrane-penetrating domain. This has been found to enable the peptide to bind to and kill cancer cells through membranolysis, or disruption of the cell membrane.

Through research and study on animal subjects, the PNC-27 peptide has been shown to be highly effective in selectively targeting a wide variety of specific forms of cancer, including pancreatic cancer, breast cancer, leukemia, melanoma, and additional cancer lines.

PNC-27 Peptide

Molecular formula: C188H293N53O44S Molar Mass: 4031.7

How Does the PNC-27 Peptide Work?

PNC proteins were first theorized and created in 2000 by Drs. Matthew Pincus and Joseph Michl at the SUNY Downstate Medical Center in New York. Although they were originally intended to combat HIV, PNC-27 showed a remarkable ability to bind to cancer cells, causing them to die, while leaving healthy cells undamaged.

The PNC-27 cancer peptide is a nontoxic compound that causes the death of cancer cells only, leaving all other healthy cells unaffected. It is able to do this by attaching to the membranes of the individual cancer cells, creating holes in those membranes. As a result of the holes, rapid implosion occurs, leading to swift cell death due to the osmotic pressure difference in the inside vs. outside of the tumor cells.

PNC-27 accomplishes this due to its affinity for binding to a protein called HDM-2. Cancer cells have HDM-2 in their cell membranes. When the PNC-27 peptide is administered, it immediately travels to the HDM-2 located in the membranes of cancerous cells. By binding to them, it creates pores or holes in the cell membrane, causing “membranolysis,” or death of the cell membrane. This in turn leads to the destruction of the cancer cell.

Clinical Studies of the PNC-27 Peptide

In a paper published by the American Association for Cancer Research in 2010, Drs. Ehsan Sarafraz-Yazdi et al. revealed in depth how the PNC-27 cancer peptide exerted its effects and what its novel mechanism of action meant for the field of cancer research.[5] The paper’s authors reported that the peptide’s mechanism of action is due to the formation of oligomeric pores in the plasma membrane of tumor cells. Concurrently, oligomeric pores are not formed in untransformed, or non-tumor, cells. Further, they noted that it has been shown that MDM2 as a targeting molecule leads to PNC-27 selectivity towards cancer cells by its mis-localization to cancer cell plasma membranes.

Researchers concluded that these findings are descriptive of the unique localization of MDM2 variants in the plasma membranes of cancerous cells.[5] Further, they stated that this knowledge may hint at great promise for the PNC-27 peptide as a future anti-cancer drug pending clinical trials.

The PNC-27 research peptide has even been the subject of a fascinating Ted Talk. It can be seen conducted by Dr. Sarafraz-Yazdi, an Assistant Professor in the Division of Gynecologic Oncology at The State University of New York (SUNY).

PNC-27 Peptide Reviews

When the PNC-27 peptide is administered in animal studies, certain aspects have been noted in successful outcomes. Researchers have noted pain levels subjectively drop in a mean time of about a week. By the 3 week mark, animal subjects often present with flu-like symptoms, a likely indicator that subjects’ immune systems are responding to the death of cancer cells.

At 6 weeks, lactate dehydrogenase and bilirubin levels typically increase. Substantial tumor breakdown in successful research outcomes is often observed at around the 10 week mark. At this time, the tumors are noted to become softer and more pliable.

Some increase in the size of the tumor itself may be noted at this time. However, this is often due to inflammation because of immune system response. By the end of 3 months, researchers often notice animal study subjects to exhibit increased energy levels and reduced cancer-related symptoms.

PNC-27 Side Effects in Studies

PNC-27 side effects have been observed in animal studies. These have included skin and nose inflammation, watery eyes, dry skin, high blood pressure, headache, back pain, nosebleed, rectal bleeding, taste change, and too much protein in the urine.

PNC-27 Clinical Trials

In a 2009 study, researchers found that the previously established 3 dimensional structure of PNC-27’s p53 residues was directly superimposable on the structure for the same residues bound to HDM-2. This led the researchers to infer that PNC-27 could target HDM-2 in cancer cells’ membranes.

Notably, cancer cells have significant levels of HDM-2 in their membranes, while untransformed or noncancerous cells do not have significant levels of HDM-2. This allows the PNC-27 peptide to selectively target the cancerous cells, leaving undamaged the healthy surrounding tissue.

Upon further experimentation, it was discovered that by implanting untransformed cells not susceptible to PNC-27 with HDM-2 containing a membrane localization signal, these cells then became susceptible to PNC-27. As a result, this constituted further evidence that the PNC-27 peptide was able to selectively target HDM-2 in the membranes of cancer cells and destroy them via membranolysis, all while leaving healthy cells unharmed.

Further, in a 2010 study published in Cancer Chemotherapy and Pharmacology, researchers determined that PNC-27 exerts its cancer cell destroying effects as a whole peptide, not fragments. With the knowledge that the peptide forms transmembrane pores in the cancer cell membrane, researchers set out to determine whether these pores were created by parts of the peptide (fragments) or by the entire peptide itself.

During the experiment, it was shown that it was indeed the entire peptide that exerts its effects in the cell membrane of cancer cells. Further, it was observed that other nontransformed, or noncancerous, cells around the cancer cells “remained viable.” From the results of the experiment, researchers gleaned that the PNC-27 cancer peptide targeted specific markers in the membranes of cancer cells. Also, via this mechanism of action, PNC-27’s lifetime is increased.

PNC-27 Peptide Destroys Cancer Cells

In a 2006 study published in the International Journal of Cancer, researchers found that PNC-28, a forerunner to the PNC-27 peptide very similar in its structure and effects, was able to selectively inhibit pancreatic cancer cell growth in vivo. Study observers noted that the peptide induced necrosis, but not apoptosis, in a variety of tumor cell lines, including ras-transformed rat acinar pancreatic carcinoma cell line known as BMRPA1. In addition, the peptide had no effect on untransformed (normal) cells. As a result, researchers looked to determine if the cancer killing peptide could block the growth of pancreatic cancer cells in vivo.

Amazingly, researchers observed that when the cancer killing peptide was administered, it caused a complete blockade of any tumor growth during its 2-week period of administration and 2 weeks post-treatment. This was followed by weak tumor growth that plateaued at low tumor sizes compared with tumor growth in the presence of a control peptide.

Further, when the cancer killing peptide PNC-27 was administered after tumor growth had occurred at a remote site from the tumor, a decrease in tumor size followed by a slow increase in tumor growth that was “significantly slower than growth in the presence of control peptide” was observed to occur. Consequently, the study researchers concluded that the cancer killing peptide may be effective in treating cancer, especially if it was administered directly to the tumor itself.

PNC-27 Anti-Cancer Peptide Studies

In a more recent study conducted in 2014 and published in Annals of Clinical & Laboratory Science, researchers concluded that “the anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue mammalian leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells.”[3]

Essentially, researchers built on knowledge gained from earlier experimentation that the PNC-27 peptide was able to destroy solid tissue tumor cells by binding to HDM-2 proteins in their cell membranes, an effect independent of p53 activity in those cells. The scientists sought to determine whether PNC-27 peptide would be similarly effective against non-solid tissue tumor cells.

This experiment would determine whether such non-solid tissue tumor cells actually expressed HDM-2 in their membranes in the first place (as the solid tissue cells were found to), and find whether PNC-27 could induce cell death in these cells through the same HDM-2 binding mechanism.

Incredibly, it was observed that these non-solid tumor cells do express HDM-2 in cell membranes.[3] Also, perhaps even more importantly, it was found that the PNC-27 peptide could induce cell necrosis through membranolysis via the same HDM-2 binding mechanism as in solid tissue tumor cells, independent of the p53 pathway.[3]

PNC-27 exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. PNC-27 for sale at Peptide  review is limited to educational and scientific research only, not for human consumption. Only buy PNC-27 if you are a licensed researcher.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.


Where to Buy PNC-27 Online

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Top-Ranked Vendor

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Peptide Hubs
Peptide Hubs
Verified Vendor

COA Transparency

Score: 8/10

Testing Documentation & Verification

Peptide Hubs markets itself as a supplier of research peptides and related laboratory compounds. The company emphasizes product quality, purity standards, and analytical testing procedures designed to support research applications.

Product information is generally organized and includes technical details intended to help customers evaluate available compounds. The company promotes quality-control measures and manufacturing consistency across its portfolio.

While transparency appears solid, wider availability of batch-specific Certificates of Analysis (COAs), third-party laboratory testing reports, and independent verification documentation would further strengthen buyer confidence.

Assessment

Peptide Hubs demonstrates a clear commitment to quality standards, though expanded public testing documentation would improve overall transparency.


Reputation

Score: 8/10

Customer Feedback & Online Presence

Peptide Hubs maintains a professional online presence focused on research products and customer service. The company appears positioned toward researchers and buyers seeking access to popular peptide compounds and specialty research materials.

Its product presentation, organization, and focus on customer support contribute positively to credibility. The supplier has developed a growing presence within the research-compound marketplace.

Independent review volume appears moderate, and prospective buyers may benefit from conducting routine due diligence before large purchases.

Assessment

A professional business presentation and research-focused approach support a generally favorable reputation.


Pricing

Score: 9/10

Product Value & Cost Competitiveness

Pricing is one of Peptide Hubs' stronger competitive advantages. The company appears to offer competitive rates across a broad selection of research compounds.

Volume discounts, wholesale opportunities, and bundled purchasing options help improve value for repeat buyers and larger research projects.

Assessment

Competitive pricing and broad product availability create strong value for research customers.


Policies

Score: 8/10

Customer Protection & Transparency

Peptide Hubs provides customer-support channels and purchasing information intended to simplify the ordering process.

The company appears focused on maintaining responsive communication and a straightforward customer experience. Product information is generally easy to access and navigate.

More publicly available information regarding returns, refunds, warranties, and dispute-resolution procedures would further strengthen policy transparency.

Assessment

Customer-support accessibility contributes positively to buyer confidence.


Shipping

Score: 8/10

Delivery Coverage & Fulfillment

Shipping appears to be a reliable operational area. The company promotes order fulfillment services designed to support efficient delivery and customer satisfaction.

Secure packaging, shipment processing, and logistics support help improve the overall purchasing experience.

Assessment

Reliable fulfillment practices contribute positively to customer satisfaction.


Catalog

Score: 9/10

Product Selection & Inventory Depth

Peptide Hubs offers a broad range of peptide and research compounds.

Metabolic Research Products

  • Tirzepatide

  • Retatrutide

  • Semaglutide

  • Cagrilintide

Recovery & Regenerative Peptides

  • BPC-157

  • TB-500

  • GHK-Cu

  • KPV

Growth Hormone Research Products

  • Tesamorelin

  • Ipamorelin

  • CJC-1295

  • Sermorelin

Longevity & Cellular Research

  • MOTS-C

  • SS-31

  • NAD+ Related Compounds

Specialty Research Products

  • Peptide Blends

  • Experimental Research Compounds

  • Laboratory Support Materials

Assessment

The catalog provides strong coverage across several major peptide-research categories while supporting both individual and commercial purchasing needs.


What We Like

Strengths

  • Competitive pricing.

  • Broad peptide selection.

  • User-friendly website.

  • Growing market presence.

  • Variety of research compounds.

  • Wholesale purchasing options.

  • Customer-focused service.

  • Organized product catalog.

  • Research-oriented business model.


What Could Be Better

Areas for Improvement

  • More publicly available batch-specific COAs.

  • Expanded third-party testing visibility.

  • Greater independent customer-review volume.

  • Enhanced manufacturing transparency.

  • More detailed refund and return information.

  • Additional educational resources for researchers.


Online Ratings & Reviews

Key Positive Themes

  • Competitive pricing.

  • Broad product selection.

  • Easy ordering process.

  • Product availability.

  • Responsive support.

Key Negative Themes

  • Limited third-party review volume.

  • Desire for additional testing transparency.

  • More publicly available documentation requested.

Overall Public Sentiment

Overall sentiment appears generally positive, with customers appreciating product availability, affordability, and ease of purchasing.

Most Common Praise

  • Product variety.

  • Value for money.

  • Customer support.

  • Research-focused catalog.

  • Ordering convenience.

Most Common Concerns

  • Limited independent reviews.

  • Additional testing documentation desired.

  • Greater company transparency requested.


Brand Overview

Company Name

Peptide Hubs

Industry

Research Peptides, Biotechnology Products & Research Compounds

Main Products

  • Tirzepatide

  • Retatrutide

  • Semaglutide

  • Cagrilintide

  • BPC-157

  • TB-500

  • GHK-Cu

  • MOTS-C

  • Tesamorelin

  • CJC-1295

Headquarters

United States-Oriented Research Supply Business

Shipping Regions

Domestic and International Availability

Payment Methods

  • Online Payment Solutions

  • Alternative Payment Methods

  • Commercial Purchasing Arrangements


Company Summary

Peptide Hubs is a research-focused supplier offering peptides, research compounds, and related laboratory products. The company emphasizes accessibility, competitive pricing, and customer support while serving researchers and procurement customers seeking popular peptide compounds.

Its catalog includes compounds commonly used in metabolic, regenerative, hormonal, and longevity-related research. Through a combination of product variety and value-oriented pricing, the company aims to provide convenient access to research materials.


Final Verdict

Peptide Hubs offers a solid mix of affordability, catalog depth, and customer accessibility. The company's strongest advantages include competitive pricing, broad product availability, and a straightforward purchasing experience.

While expanded third-party testing transparency and a larger body of independent customer reviews would further strengthen credibility, Peptide Hubs presents a reasonable option for buyers seeking a wide selection of research compounds at competitive prices.

Final Rating: 8.4/10

9.0Trust Score
Starts from $50.00

Chemical Properties & Handling

Molecular Profile
CAS NumberN/A
FormulaC188H293N53O44S
Target Purity≥ 99%
Storage Guidelines

Standard storage protocols for lyophilized peptides generally apply unless otherwise specified.

  • Lyophilized (Powder): Store at -20°C for up to 3 years. Keep away from direct light and moisture.
  • Reconstituted (Liquid): Store at 2-8°C (refrigerated) and use within 20-30 days to maintain stability.

Research Reviews

No Research Reviews Yet

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Best PNC-27 Vendors & Price Comparison

What is PNC-27?

PNC-27 is a synthetically created peptide designed to specifically target and destroy cancer cells. It is a member of the PNC set of investigational proteins designed to attach to malformed (cancerous) cells and cause them to die through cell necrosis, all while leaving normal, healthy cells intact and unharmed.

The PNC-27 peptide contains an HDM-2 binding domain corresponding to residues 12-26 of p53 and a transmembrane-penetrating domain. This has been found to enable the peptide to bind to and kill cancer cells through membranolysis, or disruption of the cell membrane.

Through research and study on animal subjects, the PNC-27 peptide has been shown to be highly effective in selectively targeting a wide variety of specific forms of cancer, including pancreatic cancer, breast cancer, leukemia, melanoma, and additional cancer lines.

PNC-27 Peptide

Molecular formula: C188H293N53O44S Molar Mass: 4031.7

How Does the PNC-27 Peptide Work?

PNC proteins were first theorized and created in 2000 by Drs. Matthew Pincus and Joseph Michl at the SUNY Downstate Medical Center in New York. Although they were originally intended to combat HIV, PNC-27 showed a remarkable ability to bind to cancer cells, causing them to die, while leaving healthy cells undamaged.

The PNC-27 cancer peptide is a nontoxic compound that causes the death of cancer cells only, leaving all other healthy cells unaffected. It is able to do this by attaching to the membranes of the individual cancer cells, creating holes in those membranes. As a result of the holes, rapid implosion occurs, leading to swift cell death due to the osmotic pressure difference in the inside vs. outside of the tumor cells.

PNC-27 accomplishes this due to its affinity for binding to a protein called HDM-2. Cancer cells have HDM-2 in their cell membranes. When the PNC-27 peptide is administered, it immediately travels to the HDM-2 located in the membranes of cancerous cells. By binding to them, it creates pores or holes in the cell membrane, causing “membranolysis,” or death of the cell membrane. This in turn leads to the destruction of the cancer cell.

Clinical Studies of the PNC-27 Peptide

In a paper published by the American Association for Cancer Research in 2010, Drs. Ehsan Sarafraz-Yazdi et al. revealed in depth how the PNC-27 cancer peptide exerted its effects and what its novel mechanism of action meant for the field of cancer research.[5] The paper’s authors reported that the peptide’s mechanism of action is due to the formation of oligomeric pores in the plasma membrane of tumor cells. Concurrently, oligomeric pores are not formed in untransformed, or non-tumor, cells. Further, they noted that it has been shown that MDM2 as a targeting molecule leads to PNC-27 selectivity towards cancer cells by its mis-localization to cancer cell plasma membranes.

Researchers concluded that these findings are descriptive of the unique localization of MDM2 variants in the plasma membranes of cancerous cells.[5] Further, they stated that this knowledge may hint at great promise for the PNC-27 peptide as a future anti-cancer drug pending clinical trials.

The PNC-27 research peptide has even been the subject of a fascinating Ted Talk. It can be seen conducted by Dr. Sarafraz-Yazdi, an Assistant Professor in the Division of Gynecologic Oncology at The State University of New York (SUNY).

PNC-27 Peptide Reviews

When the PNC-27 peptide is administered in animal studies, certain aspects have been noted in successful outcomes. Researchers have noted pain levels subjectively drop in a mean time of about a week. By the 3 week mark, animal subjects often present with flu-like symptoms, a likely indicator that subjects’ immune systems are responding to the death of cancer cells.

At 6 weeks, lactate dehydrogenase and bilirubin levels typically increase. Substantial tumor breakdown in successful research outcomes is often observed at around the 10 week mark. At this time, the tumors are noted to become softer and more pliable.

Some increase in the size of the tumor itself may be noted at this time. However, this is often due to inflammation because of immune system response. By the end of 3 months, researchers often notice animal study subjects to exhibit increased energy levels and reduced cancer-related symptoms.

PNC-27 Side Effects in Studies

PNC-27 side effects have been observed in animal studies. These have included skin and nose inflammation, watery eyes, dry skin, high blood pressure, headache, back pain, nosebleed, rectal bleeding, taste change, and too much protein in the urine.

PNC-27 Clinical Trials

In a 2009 study, researchers found that the previously established 3 dimensional structure of PNC-27’s p53 residues was directly superimposable on the structure for the same residues bound to HDM-2. This led the researchers to infer that PNC-27 could target HDM-2 in cancer cells’ membranes.

Notably, cancer cells have significant levels of HDM-2 in their membranes, while untransformed or noncancerous cells do not have significant levels of HDM-2. This allows the PNC-27 peptide to selectively target the cancerous cells, leaving undamaged the healthy surrounding tissue.

Upon further experimentation, it was discovered that by implanting untransformed cells not susceptible to PNC-27 with HDM-2 containing a membrane localization signal, these cells then became susceptible to PNC-27. As a result, this constituted further evidence that the PNC-27 peptide was able to selectively target HDM-2 in the membranes of cancer cells and destroy them via membranolysis, all while leaving healthy cells unharmed.

Further, in a 2010 study published in Cancer Chemotherapy and Pharmacology, researchers determined that PNC-27 exerts its cancer cell destroying effects as a whole peptide, not fragments. With the knowledge that the peptide forms transmembrane pores in the cancer cell membrane, researchers set out to determine whether these pores were created by parts of the peptide (fragments) or by the entire peptide itself.

During the experiment, it was shown that it was indeed the entire peptide that exerts its effects in the cell membrane of cancer cells. Further, it was observed that other nontransformed, or noncancerous, cells around the cancer cells “remained viable.” From the results of the experiment, researchers gleaned that the PNC-27 cancer peptide targeted specific markers in the membranes of cancer cells. Also, via this mechanism of action, PNC-27’s lifetime is increased.

PNC-27 Peptide Destroys Cancer Cells

In a 2006 study published in the International Journal of Cancer, researchers found that PNC-28, a forerunner to the PNC-27 peptide very similar in its structure and effects, was able to selectively inhibit pancreatic cancer cell growth in vivo. Study observers noted that the peptide induced necrosis, but not apoptosis, in a variety of tumor cell lines, including ras-transformed rat acinar pancreatic carcinoma cell line known as BMRPA1. In addition, the peptide had no effect on untransformed (normal) cells. As a result, researchers looked to determine if the cancer killing peptide could block the growth of pancreatic cancer cells in vivo.

Amazingly, researchers observed that when the cancer killing peptide was administered, it caused a complete blockade of any tumor growth during its 2-week period of administration and 2 weeks post-treatment. This was followed by weak tumor growth that plateaued at low tumor sizes compared with tumor growth in the presence of a control peptide.

Further, when the cancer killing peptide PNC-27 was administered after tumor growth had occurred at a remote site from the tumor, a decrease in tumor size followed by a slow increase in tumor growth that was “significantly slower than growth in the presence of control peptide” was observed to occur. Consequently, the study researchers concluded that the cancer killing peptide may be effective in treating cancer, especially if it was administered directly to the tumor itself.

PNC-27 Anti-Cancer Peptide Studies

In a more recent study conducted in 2014 and published in Annals of Clinical & Laboratory Science, researchers concluded that “the anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue mammalian leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells.”[3]

Essentially, researchers built on knowledge gained from earlier experimentation that the PNC-27 peptide was able to destroy solid tissue tumor cells by binding to HDM-2 proteins in their cell membranes, an effect independent of p53 activity in those cells. The scientists sought to determine whether PNC-27 peptide would be similarly effective against non-solid tissue tumor cells.

This experiment would determine whether such non-solid tissue tumor cells actually expressed HDM-2 in their membranes in the first place (as the solid tissue cells were found to), and find whether PNC-27 could induce cell death in these cells through the same HDM-2 binding mechanism.

Incredibly, it was observed that these non-solid tumor cells do express HDM-2 in cell membranes.[3] Also, perhaps even more importantly, it was found that the PNC-27 peptide could induce cell necrosis through membranolysis via the same HDM-2 binding mechanism as in solid tissue tumor cells, independent of the p53 pathway.[3]

PNC-27 exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. PNC-27 for sale at Peptide  review is limited to educational and scientific research only, not for human consumption. Only buy PNC-27 if you are a licensed researcher.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Current Research & Evidence

Research evidence for PNC-27 has not yet been added.

Key Findings on PNC-27 Use

Key findings for PNC-27 have not yet been added.

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