PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.

CJC-1295 Overview

Growth hormone releasing hormone (GHRH) has been modified a number of times to produce analogues that preserve some of the hormone’s effects while eliminating others. One of those modifications, CJC-1295, consists of just the first 29 amino acids of GHRH. This analogue of GHRH, which is technically a maleimido derivative of hGRF(1-29), was created in an effort to produce a more soluble GH secretagogue that is easier to produce in large quantities but still preserves the physiologic actions of GHRH.

CJC-1295 Versus CJC-1295 DAC

CJC-1295 is a modified version of the first 29 amino acids of GHRH, which means it is chemically similar to other GHRH analogues, like Sermorelin. It is most similar to modified GRF (1-29), but the two peptides are not identical. A great deal of confusion arises because of the similarities between these peptides and because CJC-1295 was originally created with an added chemical compound called the drug affinity complex (DAC).

DAC is added to the molecule, with the help of a lysine linker, to protect the peptide while it circulates in the blood stream. By allowing peptides to bind to the common blood protein albumin, DAC helps to ensure that the half-life of 

CJC-1295 is much longer than similar molecules like GRF (1-29).

Half-life of CJC-1295-DAC compared to standard growth hormone releasing factor (GRF) Source: Oxford Academic

Originally, ConjuChem Biotechnologies, the developer of DAC, referred to the molecule containing DAC as simply CJC-1295. Confusion arose, however, because the peptide was also being offered without DAC. To avoid confusion, CJC-1295 that contains DAC is called CJC-1295-DAC and when it does not contain DAC it is referred to as CJC-1295 or CJC-1295-no DAC.

CJC-1295 Structure  

Source: Oxford Academic

Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg Molecular Formula: C152H252N44O42 Molecular Weight: 3367.954 g/mol PubChem CID: 56841945

CJC-1295-DAC Structure

Source: Oxford Academic

Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys-DAC Molecular Formula: C152H252N44O42 Molecular Weight: 3647.954 g/mol PubChem CID: 91976842

CJC-1295 Research

CJC-1295 and Growth Hormone Release

As a derivative of GHRH, it should come as no surprise that CJC-1295 promotes the release of GH. Studies show that a single dose of CJC-1295 increase GH levels in mice by 2-10 times. Peak GH levels are reached approximately 2 hours after administration and the effects last for about six days. Unlike other GH secretagogues, CJC-1295 preserves normal physiologic release of GH[1]. That means that the normal circadian peaks and valleys seen in GH release remain intact and that CJC-1295 is a physiologic growth hormone releasing factor.

Preserving physiologic release of GH even while influencing the maximum concentration of the hormone in the bloodstream is critical to ensuring enhanced effects without increased side effects. In particular, CJC-1295 has been demonstrated to preserve growth hormone’s physiologic effects on hyperplasia, hypertrophy, bone density, blood sugar, fat metabolism, protein synthesis, and myocardial (heart cell) function.

CJC-1295 and Growth

Studies in mice without normal GHRH physiology have shown that CJC-1295 preserves normal GH release[2]. This makes the peptide potentially useful as a therapy for abnormal growth in a variety of mammalian species, humans included. Preserving normal pulsatile release of GH is critical to ensuring that proper release of downstream hormones, such as insulin-life growth factor-2 (IGF-1).

CJC-1295 and Infertility

Research from the early 1990s suggests that CJC-1295 and other GRF analogues may be useful in promoting ovulation in infertile female patients. Scientists have long known that ovulation is dependent on IGF-1 and that it is also likely influenced by GH release and cycling. Research in animal models of superovulation has helped to confirm these theories by showing that both GH and IGF-1 levels rise significantly surrounding the time of ovulation. Further, these studies indicate that exogenous administration of GH secretagogues, like CJC-1295, is enough to cause appropriate ovulation[3]. There is some speculation that CJC-1295 and other analogues may even be useful in male infertility by helping to regulate sperm production. This latter hypothesis has yet to be tested.

CJC-1295 Summary

CJC-1295 is a growth hormone secretagogue designed to have a long plasma half-life and to preserve the physiologic patterns inherent in the GH axis. On both accounts, the molecule has been a success. CJC-1295 has experienced limited interest in research settings due to the advent of a number of similar molecules and because of the proprietary nature of the molecule’s structure. Now that CJC-1295 can be manufactured at will, there is likely to be renewed interest in its properties, particularly as they apply to the increasingly frustrating problem of human infertility.

CJC-1295 exhibits moderate side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. CJC-1295 for sale at Peptide review is limited to educational and scientific research only, not for human consumption. Only buy CJC-1295 if you are a licensed researcher.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Scientific Journal Author

Dr. Dominique Bridon holds a Master of Science, Chemical Engineering and Polymer Sciences from Ecole Nationale Supérieure de Chimie and a PhD in Organic Chemistry from the University of Paris XI, ICSN, Orsay, France with Nobel Laureate Sir Derek H. R. Barton as Research Advisor. He completed his Post-Doctoral Research at the University of California, Berkeley. He studied the potential of CJC-1295 as a long lasting GRF analog and also held various leadership positions involving peptide research and technologies at Ipsen, Conjuchem, Redcell, and Abbott Laboratories. Dr. Bridon has served as a Director for Enobia (acquired by Alexion) and Neuronax and as a member of the Scientific Advisory Board of Syntaxin (acquired by Ipsen) and Biosortia. He now brings 30 years of executive and scientific leadership experience to the Epivax Oncology team.

Dr. Dominique Bridon is being referenced as one of the leading scientists involved in the research and development of CJC-1295. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Peptide review and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Dr. Dominique Bridon is listed in [4] under the referenced citations.

Referenced Citations

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body.  These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease.  Bodily introduction of any kind into humans or animals is strictly forbidden by law.

CJC-1295 DAC is one of the most widely researched growth hormone-releasing hormone (GHRH) analogues in peptide science. Developed as a modified derivative of GHRH, CJC-1295 DAC incorporates a Drug Affinity Complex (DAC) designed to extend circulation time and significantly increase the peptide's half-life compared to traditional GHRH analogs.

As interest in growth hormone signaling, endocrine biology, aging research, body composition studies, and reproductive biology continues to expand, researchers increasingly compare CJC-1295 DAC suppliers based on pricing, purity, testing standards, and overall quality assurance.

This CJC-1295 DAC Vendor Price Comparison Guide helps researchers compare peptide suppliers using objective criteria, including:

• Product Pricing

• Cost Per Milligram

• Peptide Purity

• Third-Party Testing

• Certificate of Analysis (COA)

• Vendor Reputation

• Customer Reviews

• Shipping Performance

• Product Availability

• Overall Value

Whether you're looking for the most affordable CJC-1295 DAC vendor, suppliers offering extensive laboratory testing, or highly rated peptide companies, this guide can help identify the best research source.

Explore CJC-1295 DAC Vendors by Criteria

Most Popular CJC-1295 DAC Vendors

Discover peptide suppliers most frequently selected by growth hormone and endocrine researchers.

Highest Reviewed CJC-1295 DAC Vendors

Compare vendors with strong customer satisfaction and long-standing marketplace reputations.

Lowest Price CJC-1295 DAC Vendors

Identify suppliers offering competitive pricing and attractive cost-per-milligram value.

Highest Purity CJC-1295 DAC Vendors

Review vendors providing extensive purity testing and transparent analytical reporting.

Best Value CJC-1295 DAC Vendors

Compare quality standards, testing transparency, customer support, and pricing.

Fastest Shipping CJC-1295 DAC Vendors

Evaluate fulfillment speed, packaging reliability, and order-processing performance.

Newly Listed CJC-1295 DAC Vendors

Explore recently added peptide suppliers offering CJC-1295 DAC research products.

What Is CJC-1295 DAC?

Overview

CJC-1295 DAC is a modified growth hormone-releasing hormone (GHRH) analogue designed to stimulate endogenous growth hormone release while preserving natural physiologic secretion patterns.

The peptide was developed from the first 29 amino acids of human GHRH and modified to improve stability and duration of action.

Researchers have investigated CJC-1295 DAC in studies involving:

• Growth hormone signaling

• IGF-1 regulation

• Endocrine biology

• Body composition research

• Bone metabolism

• Aging biology

• Reproductive research

One of the primary features distinguishing CJC-1295 DAC from other GHRH analogues is its extended half-life.

CJC-1295 DAC vs CJC-1295 No DAC

Understanding the Difference

A common source of confusion involves the distinction between:

• CJC-1295 DAC

• CJC-1295 No DAC (Modified GRF 1-29)

While both compounds originate from similar GHRH-based structures, they are not identical.

What Is DAC?

DAC stands for Drug Affinity Complex.

This modification allows the peptide to bind with serum albumin in circulation, increasing its half-life and extending biological activity.

Why Researchers Use CJC-1295 DAC

Researchers often prefer CJC-1295 DAC when studying:

• Long-duration GH signaling

• Sustained IGF-1 elevation

• Extended peptide exposure models

• Endocrine regulation pathways

Molecular Characteristics

Peptide Information

Researchers should review the following molecular specifications when evaluating CJC-1295 DAC products.

Peptide Name

CJC-1295 DAC

Classification

Growth Hormone Releasing Hormone (GHRH) Analogue

Amino Acid Sequence

Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys-DAC

Molecular Weight

3647.954 g/mol

PubChem CID

91976842

Peptide Type

Long-Acting Growth Hormone Secretagogue

Why Vendor Quality Matters

Not all peptide suppliers maintain identical manufacturing and quality-control standards.

Differences between vendors may include:

• Peptide purity

• Batch consistency

• DAC stability

• Manufacturing protocols

• Storage procedures

• Independent testing

• Product handling

• Shipping quality

A lower-priced peptide product may not provide the same quality assurance as one supported by transparent laboratory documentation.

How We Compare CJC-1295 DAC Vendors

Third-Party Laboratory Testing

Independent laboratory testing remains one of the strongest indicators of peptide quality.

Researchers should prioritize vendors providing:

• Third-party verification

• Batch-specific testing

• Identity confirmation

• Purity analysis

Certificate of Analysis (COA)

A high-quality COA should include:

• Test date

• Lot number

• Purity percentage

• Peptide identity verification

• Analytical methodology

Product Purity

Purity is one of the most important quality indicators when evaluating CJC-1295 DAC products.

Suppliers providing transparent purity data generally receive stronger quality ratings.

Cost Per Milligram

Bottle pricing alone often creates misleading comparisons.

Cost Per Milligram Formula

Product Price ÷ Total Milligrams = Cost Per Milligram

Using cost-per-milligram calculations provides a more accurate comparison between vendors.

Customer Reviews

Customer reviews often reveal valuable information regarding:

• Product consistency

• Packaging quality

• Shipping reliability

• Customer support

• Overall purchasing experience

Vendor Reputation

Established suppliers often demonstrate:

• Consistent quality standards

• Strong customer satisfaction

• Reliable inventory management

• Transparent business practices

Current Research & Evidence

Growth Hormone Research

CJC-1295 DAC has been extensively studied because of its ability to stimulate endogenous growth hormone release.

Research has demonstrated sustained elevations in growth hormone levels following administration in experimental settings.

IGF-1 Regulation Research

Researchers frequently investigate the relationship between CJC-1295 DAC and insulin-like growth factor-1 (IGF-1) signaling.

Because GH and IGF-1 are closely connected, this pathway remains a major focus of endocrine research.

Endocrine System Research

CJC-1295 DAC serves as a valuable tool for studying:

• Pituitary signaling

• Hormonal regulation

• Growth-factor pathways

• Endocrine physiology

Aging Research

Research interest has grown around age-related changes in growth hormone signaling and how these pathways influence biological aging processes.

Reproductive Biology Research

Some experimental studies have explored interactions between growth hormone signaling and reproductive physiology, including ovulation and fertility-associated pathways.

Key Findings on CJC-1295 DAC Research

Extended Half-Life

The most significant feature of CJC-1295 DAC is its ability to remain active substantially longer than many traditional GHRH analogues.

This property makes it particularly useful for long-duration hormone signaling studies.

Physiologic GH Release

Unlike direct growth hormone administration, CJC-1295 DAC has been studied for its ability to preserve natural growth hormone secretion patterns.

Researchers continue investigating how physiologic hormone release differs from exogenous hormone delivery.

Growth Hormone Elevation

Experimental studies have demonstrated substantial increases in circulating growth hormone concentrations following administration.

IGF-1 Research

Researchers have observed corresponding increases in IGF-1 levels in various experimental models.

Body Composition Research

Growth hormone signaling has long been associated with body composition, muscle biology, and metabolic regulation.

Researchers continue using CJC-1295 DAC to investigate these pathways.

Bone Metabolism Research

Experimental research has evaluated how growth hormone and IGF-1 signaling influence bone remodeling and skeletal biology.

Research Limitations

Most findings remain dependent upon experimental design, dosage, species differences, and study conditions.

Research outcomes should not be interpreted as evidence of approved therapeutic use in humans.

Product Quality & Analytical Testing

Why Testing Matters

Research-grade CJC-1295 DAC should undergo analytical verification to confirm:

• Peptide identity

• Purity

• Stability

• DAC integrity

• Batch consistency

Common Testing Methods

High-Performance Liquid Chromatography (HPLC)

Used to determine peptide purity and identify impurities.

Mass Spectrometry (MS)

Used to verify molecular mass and peptide identity.

Peptide Mapping

Provides additional confirmation of peptide structure.

Batch Verification

Used to compare quality across production lots.

Stability Testing

Evaluates peptide integrity under specified storage conditions.

Understanding CJC-1295 DAC Pricing

Several factors can influence supplier pricing.

Purity Standards

Higher-purity peptide preparations frequently command premium prices.

DAC Formulation Complexity

The DAC modification introduces additional manufacturing and quality-control requirements.

Third-Party Testing

Comprehensive testing programs improve transparency but increase production costs.

Manufacturing Standards

Advanced production and quality-control systems may contribute to higher pricing.

Vendor Reputation

Trusted peptide suppliers often charge premium pricing based on reliability and consistency.

CJC-1295 DAC Vendor Evaluation Checklist

Quality Verification

✅ Third-party testing available

✅ Certificate of Analysis provided

✅ Batch-specific testing

✅ Identity verification documented

✅ Purity information disclosed

Vendor Reliability

✅ Positive customer reviews

✅ Transparent company information

✅ Responsive support

✅ Consistent inventory availability

Ordering Experience

✅ Secure checkout process

✅ Tracking provided

✅ Reliable fulfillment

✅ Clear refund policies

Red Flags When Comparing Vendors

Testing Concerns

❌ Missing COAs

❌ No third-party testing

❌ Unverified purity claims

❌ Outdated analytical reports

Transparency Issues

❌ No batch numbers

❌ Hidden testing data

❌ Limited product specifications

❌ Missing contact information

Service Problems

❌ Consistently negative reviews

❌ Frequent stock shortages

❌ Poor customer communication

❌ Unclear shipping policies

How to Choose the Best CJC-1295 DAC Vendor

Prioritize Quality

Look for suppliers with transparent purity testing and batch-specific COAs.

Compare Overall Value

Balance pricing against testing standards, peptide purity, and supplier reputation.

Verify Product Documentation

Review analytical reports before purchasing any research peptide.

Evaluate Vendor Reputation

Long-established vendors often demonstrate stronger quality control and customer satisfaction.

Match the Product to Research Goals

Select suppliers offering appropriate vial sizes, documentation, and testing standards for your specific laboratory requirements.

Frequently Asked Questions

What is CJC-1295 DAC?

CJC-1295 DAC is a long-acting GHRH analogue that incorporates a Drug Affinity Complex (DAC) to extend circulation time and support prolonged growth hormone signaling research.

What is the difference between CJC-1295 and CJC-1295 DAC?

CJC-1295 DAC contains the Drug Affinity Complex modification, which significantly increases half-life compared to CJC-1295 without DAC.

Why compare CJC-1295 DAC vendors?

Product purity, testing standards, analytical documentation, pricing, and supplier reliability can vary significantly between vendors.

What should I look for before purchasing?

Researchers should review:

• Third-party testing

• COA availability

• Purity specifications

• Batch verification

• Vendor reputation

• Customer reviews

Why is third-party testing important?

Independent testing helps verify product identity, purity, and consistency.

Is the cheapest supplier always the best option?

Not necessarily. Product quality and testing transparency are often more important than price alone.

How often should vendor comparisons be updated?

Pricing, laboratory documentation, inventory availability, and supplier policies can change frequently and should be reviewed regularly.

Final Thoughts

CJC-1295 DAC remains one of the most extensively studied long-acting GHRH analogues in endocrine and growth hormone research. Its extended half-life, ability to preserve physiologic GH release patterns, and influence on IGF-1 signaling continue to make it an important research tool in studies involving metabolism, aging biology, body composition, bone physiology, and reproductive science.

Researchers comparing CJC-1295 DAC vendors should prioritize purity verification, laboratory testing, analytical documentation, supplier reputation, and overall value rather than price alone. Evaluating suppliers using objective quality criteria can help identify the most reliable peptide sources for research applications.