Mazdutide, also known as IBI362 and LY3305677, is a synthetic peptide designed to activate both the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). This dual-receptor profile has made Mazdutide an important subject of metabolic research involving energy balance, glucose regulation, lipid metabolism, and body-weight biology.

Mazdutide is structurally related to oxyntomodulin, an endogenous peptide that naturally interacts with both GLP-1 and glucagon pathways. Its molecular design incorporates modifications intended to improve stability and prolong its circulating activity, making it suitable for extended research protocols.

The product is supplied as a lyophilized research peptide and is intended strictly for laboratory research. It is not intended for human or veterinary use.

Mechanism of Action

Mazdutide is being investigated as a dual GLP-1R/GCGR agonist. Activation of GLP-1 receptors is associated with pathways involved in glucose-dependent insulin signaling, appetite regulation, and energy balance, while glucagon receptor activation is involved in hepatic glucose and lipid metabolism and energy expenditure.

Studying both pathways simultaneously allows researchers to examine how combined receptor activation influences metabolic regulation compared with selective GLP-1 receptor agonism.

Molecular Characteristics

• Product Name: Mazdutide

• Synonyms: IBI362, IBI-362, LY3305677

• CAS Number: 2259884-03-0

• Molecular Formula: C₂₁₀H₃₂₂N₄₆O₆₇

• Approximate Molecular Weight: 4,563.1 g/mol

• Receptor Profile: GLP-1R and GCGR dual agonist

• Form: Lyophilized powder

PubChem lists Mazdutide under CAS 2259884-03-0 with the molecular formula C₂₀₇H₃₁₇N₄₅O₆₅ and a calculated molecular weight of 4,476 g/mol, while commercial analytical references report a related molecular specification of C₂₁₀H₃₂₂N₄₆O₆₇ and 4,563.1 g/mol. Because peptide specifications can differ according to molecular form and analytical convention, the batch-specific Certificate of Analysis should be treated as the definitive product specification.

Research Applications

1. Metabolic Signaling Research

Mazdutide provides a research model for examining the interaction between GLP-1 and glucagon signaling. Researchers can investigate how simultaneous activation of these receptors influences energy homeostasis and metabolic pathways.

2. Glucose Regulation

GLP-1 signaling is closely associated with glucose-dependent insulin secretion, while glucagon signaling has important effects on hepatic glucose metabolism. Mazdutide therefore offers a framework for studying the interaction between these endocrine pathways.

3. Body-Composition Research

Researchers are investigating dual GLP-1R/GCGR agonism in relation to changes in body weight, fat metabolism, energy expenditure, and preservation of lean tissue.

4. Lipid and Liver Metabolism

Glucagon receptor activity has an important role in hepatic lipid metabolism. Mazdutide is consequently of interest in experimental research involving hepatic fat metabolism and metabolic liver disorders.

5. Obesity and Metabolic-Disease Models

Mazdutide has progressed through clinical research programs investigating obesity and metabolic disorders. The compound has also been recognized by the IUPHAR/BPS database as an approved drug in China as of 2025, so it should not be described simply as an untested "research chemical."

Structural Design

Mazdutide incorporates structural modifications intended to improve its stability and pharmacokinetic characteristics. Research descriptions identify modifications involving a non-natural amino-acid substitution and a lipid-containing side chain attached through a linker. These features contribute to prolonged exposure compared with native peptide hormones.

The extended molecular design makes Mazdutide particularly relevant to studies examining sustained receptor activation and longer-duration metabolic signaling.

Quality & Analytical Testing

For laboratory research, researchers should evaluate peptide identity, purity, and batch consistency using appropriate analytical documentation.

Depending on the supplier and batch, analytical characterization may include:

• HPLC for purity assessment

• Mass spectrometry for molecular-weight confirmation

• NMR or other structural techniques where applicable

• Batch-specific Certificate of Analysis (CoA)

Published commercial analytical data for Mazdutide demonstrate the type of documentation that can be used to verify molecular identity and purity.

Key Features

• Dual-Receptor Research: Investigates GLP-1R and glucagon receptor signaling simultaneously.

• Metabolic Research: Relevant to glucose, lipid, energy-balance, and body-composition studies.

• Extended-Activity Design: Structural modifications support prolonged peptide exposure.

• Lyophilized Format: Suitable for controlled laboratory research and analytical applications.

• Well-Characterized Compound: Also known as IBI362 and LY3305677.

• Analytical Documentation: Batch-specific purity and identity data should be reviewed before research use.

*Molecular specifications can vary according to the molecular form reported; consult the applicable Certificate of Analysis for the supplied material.

Research-Use Disclaimer

For research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease or medical condition. Researchers should follow applicable laboratory, regulatory, storage, handling, and disposal requirements and rely on current batch-specific documentation for product specifications.

Mazdutide, also known as IBI362 and LY3305677, is a synthetic dual-receptor peptide engineered to activate both the Glucagon-Like Peptide-1 Receptor (GLP-1R) and the Glucagon Receptor (GCGR). Its unique dual-agonist profile has made it a significant area of research in metabolic biology, energy regulation, glucose metabolism, lipid physiology, body-composition studies, and obesity-related research.

Structurally derived from the endogenous peptide oxyntomodulin, Mazdutide incorporates modifications intended to enhance stability, prolong activity, and support extended receptor engagement during laboratory investigations.

This Mazdutide Vendor Price Comparison Guide helps researchers evaluate suppliers using objective criteria including:

• Product Pricing

• Cost Per Milligram

• Product Purity

• Third-Party Testing

• Certificate of Analysis (COA)

• Vendor Reputation

• Customer Reviews

• Shipping Performance

• Product Availability

• Overall Value

Whether you're searching for the lowest-priced Mazdutide supplier, the highest-purity research material, or vendors providing extensive analytical verification, this guide provides a structured framework for comparing research peptide suppliers.

Explore Mazdutide Vendors by Criteria

Most Popular Mazdutide Vendors

Compare suppliers commonly selected by metabolic and endocrine researchers.

Highest Reviewed Vendors

Discover vendors with strong customer satisfaction and positive industry reputations.

Lowest Price Vendors

Identify suppliers offering competitive pricing and favorable cost-per-milligram value.

Highest Purity Vendors

Review suppliers providing transparent analytical testing and purity verification.

Best Value Vendors

Compare pricing, quality standards, testing documentation, and customer support.

Fastest Shipping Vendors

Evaluate fulfillment performance, packaging quality, and delivery reliability.

Newly Listed Vendors

Explore recently added suppliers offering Mazdutide research peptides.

What Is Mazdutide?

Overview

Mazdutide is a synthetic peptide designed to act as a dual agonist at:

• GLP-1 Receptor (GLP-1R)

• Glucagon Receptor (GCGR)

Researchers investigate Mazdutide because of its relationship with:

• Glucose regulation

• Energy expenditure

• Metabolic signaling

• Appetite regulation

• Lipid metabolism

• Body-composition biology

• Obesity-related pathways

• Endocrine communication

Its dual receptor activity provides researchers with an opportunity to study integrated metabolic signaling systems.

Molecular Characteristics

Peptide Information

Researchers evaluating Mazdutide products should carefully review analytical documentation and molecular specifications.

Product Name

Mazdutide

Alternative Names

• IBI362

• IBI-362

• LY3305677

Classification

Dual GLP-1R / GCGR Agonist

Research Category

Metabolic & Endocrine Research

CAS Number

2259884-03-0

Molecular Formula

C₂₁₀H₃₂₂N₄₆O₆₇*

Approximate Molecular Weight

4,563.1 g/mol*

Product Format

Lyophilized Powder

Receptor Profile

Dual GLP-1 Receptor and Glucagon Receptor Agonist

*Researchers should always rely on batch-specific Certificates of Analysis, as reported molecular specifications may vary between analytical references and molecular forms.

Why Researchers Study Mazdutide

Mazdutide has attracted substantial scientific interest because it combines the biological effects of two key metabolic receptor systems into a single research peptide.

Researchers investigate pathways involving:

• GLP-1 signaling

• Glucagon signaling

• Energy balance

• Endocrine regulation

• Metabolic homeostasis

• Glucose utilization

• Nutrient signaling

• Body-weight regulation

These remain active fields of metabolic and obesity research.

Mechanism of Action Research

Dual Receptor Activation

The primary scientific interest in Mazdutide stems from its ability to simultaneously activate:

GLP-1 Receptors

Researchers investigate pathways involving:

• Glucose-dependent signaling

• Appetite regulation

• Gastrointestinal physiology

• Endocrine communication

• Energy balance

Glucagon Receptors

Scientists continue studying pathways involving:

• Hepatic metabolism

• Energy expenditure

• Lipid utilization

• Nutrient processing

• Metabolic regulation

Integrated Signaling Research

Dual receptor activation allows researchers to investigate interactions involving:

• Hormonal communication

• Metabolic adaptation

• Nutrient sensing

• Energy homeostasis

• Endocrine regulation

This remains one of the most important areas of Mazdutide research.

Structural Engineering & Peptide Design

Oxyntomodulin-Based Design

Mazdutide is structurally related to the endogenous peptide oxyntomodulin.

Researchers investigate this design because it supports:

• Dual receptor interactions

• Metabolic signaling

• Hormonal communication

• Endocrine integration

• Energy regulation

Stability Enhancements

The peptide incorporates structural modifications intended to improve:

• Molecular stability

• Enzymatic resistance

• Experimental longevity

• Receptor engagement

• Pharmacokinetic characteristics

Extended Activity Research

Researchers investigate prolonged receptor activation because it may provide useful models for studying:

• Sustained signaling

• Chronic metabolic adaptation

• Endocrine responses

• Energy balance regulation

• Long-duration biological processes

Mazdutide & Metabolic Signaling Research

Energy Homeostasis Research

One of the most significant applications of Mazdutide involves research into energy regulation.

Scientists investigate pathways involving:

• Nutrient sensing

• Energy expenditure

• Hormonal signaling

• Metabolic communication

• Physiological adaptation

Metabolic Integration Research

Researchers study interactions involving:

• GLP-1 pathways

• Glucagon pathways

• Endocrine responses

• Nutrient utilization

• Cellular metabolism

Mazdutide & Glucose Regulation Research

Glucose Homeostasis Research

Researchers investigate pathways involving:

• Glucose regulation

• Insulin signaling

• Hormonal communication

• Metabolic adaptation

• Cellular responses

This remains a major research area.

Endocrine Communication Research

Scientists continue studying:

• Hormonal feedback systems

• Signal transduction

• Cellular regulation

• Metabolic physiology

• Glucose-related pathways

Mazdutide & Body-Composition Research

Weight Regulation Research

Researchers investigate pathways involving:

• Energy intake regulation

• Metabolic signaling

• Nutrient utilization

• Hormonal adaptation

• Body-composition biology

Adipose Tissue Research

Studies frequently examine:

• Adipocyte signaling

• Fat metabolism

• Energy storage

• Cellular communication

• Physiological adaptation

Lean-Mass Research

Researchers continue exploring:

• Metabolic partitioning

• Tissue signaling

• Nutrient allocation

• Energetic regulation

• Body-composition models

Mazdutide & Lipid Metabolism Research

Lipid Biology Research

Researchers investigate pathways involving:

• Fat metabolism

• Cellular energy use

• Nutrient utilization

• Metabolic communication

• Hormonal regulation

Hepatic Metabolism Research

Scientists continue studying:

• Liver physiology

• Lipid processing

• Endocrine signaling

• Metabolic adaptation

• Nutrient management

Metabolic Liver Research

Research includes pathways involving:

• Hepatic lipid balance

• Energy regulation

• Metabolic homeostasis

• Cellular adaptation

• Endocrine communication

Mazdutide & Obesity Research

Obesity Biology Research

Researchers investigate pathways involving:

• Appetite regulation

• Energy expenditure

• Metabolic adaptation

• Body-weight regulation

• Hormonal signaling

This remains one of the primary research applications of Mazdutide.

Dual-Agonist Research Models

Studies frequently compare:

• Selective GLP-1 agonists

• Selective glucagon agonists

• Dual GLP-1R/GCGR agonists

to better understand receptor interactions and metabolic outcomes.

Quality & Analytical Testing

Why Testing Matters

Research-grade Mazdutide products should undergo testing to verify:

• Identity

• Purity

• Molecular integrity

• Stability

• Batch consistency

Common Testing Methods

High-Performance Liquid Chromatography (HPLC)

Used to assess purity and identify potential impurities.

Mass Spectrometry (MS)

Used to verify molecular identity and molecular weight.

Structural Analysis

May include advanced techniques used to evaluate peptide integrity and composition.

Certificate of Analysis (COA)

Provides batch-specific analytical verification.

Why Researchers Compare Mazdutide Vendors

Research reproducibility depends heavily on peptide quality and manufacturing consistency.

Differences among suppliers may include:

• Product purity

• Manufacturing standards

• Analytical verification

• Batch consistency

• Stability testing

• Documentation quality

• Storage procedures

• Quality-control systems

Careful supplier selection can improve consistency across laboratory studies.

How We Compare Mazdutide Vendors

Third-Party Laboratory Testing

Researchers should prioritize suppliers offering:

✅ Third-party testing

✅ Identity verification

✅ Purity confirmation

✅ Batch-specific reports

✅ Analytical documentation

Certificate of Analysis (COA)

A quality COA should contain:

• Batch number

• Testing date

• Purity percentage

• Identity confirmation

• Testing methodology

Product Purity

Purity remains one of the most important variables when evaluating research peptides.

Higher-purity products generally contribute to improved reproducibility and consistency.

Cost Per Milligram

Comparing vial prices alone may not accurately reflect value.

Cost Per Milligram Formula

Product Price ÷ Total Milligrams = Cost Per Milligram

This metric helps standardize supplier comparisons.

Customer Reviews

Customer feedback may provide insight regarding:

• Product consistency

• Shipping reliability

• Packaging quality

• Customer support

• Overall purchasing experience

Vendor Reputation

Established peptide suppliers often demonstrate:

• Transparent testing programs

• Reliable quality-control procedures

• Consistent inventory availability

• Positive customer feedback

Storage & Handling

Researchers should follow validated laboratory procedures.

Best practices include:

✅ Protect from excessive heat

✅ Protect from moisture

✅ Minimize direct light exposure

✅ Avoid repeated freeze-thaw cycles

✅ Review batch-specific documentation

✅ Follow validated storage procedures

✅ Use sterile laboratory handling techniques

Proper handling helps preserve peptide stability and research consistency.

Understanding Mazdutide Pricing

Several factors influence supplier pricing.

Product Complexity

Dual-receptor peptides typically require advanced synthesis and purification methods.

Product Purity

Higher-purity preparations generally command premium pricing.

Analytical Testing

Comprehensive testing improves transparency while increasing production costs.

Research Demand

Growing interest in obesity and metabolic research contributes to market demand.

Vendor Reputation

Suppliers with rigorous quality-control systems often command higher pricing.

Mazdutide Vendor Evaluation Checklist

Quality Verification

✅ Third-party testing available

✅ Certificate of Analysis provided

✅ Identity verification documented

✅ Purity information disclosed

✅ Stability testing available

✅ Batch-specific reports available

Vendor Reliability

✅ Positive customer reviews

✅ Transparent company information

✅ Responsive customer support

✅ Reliable inventory availability

Purchasing Experience

✅ Secure checkout process

✅ Shipment tracking available

✅ Clear return policies

✅ Reliable order fulfillment

Frequently Asked Questions

What is Mazdutide?

Mazdutide (IBI362, LY3305677) is a synthetic peptide investigated as a dual agonist of the GLP-1 receptor and glucagon receptor.

What is Mazdutide used for in research?

Researchers investigate Mazdutide in studies involving glucose regulation, energy metabolism, appetite signaling, lipid metabolism, obesity models, body-composition biology, and metabolic regulation.

What makes Mazdutide different from traditional GLP-1 agonists?

Mazdutide activates both GLP-1R and GCGR pathways, allowing researchers to evaluate integrated metabolic signaling rather than only GLP-1 receptor activity.

What should researchers review before purchasing?

Researchers should evaluate:

• Certificate of Analysis (COA)

• Third-party testing

• HPLC purity verification

• Mass spectrometry confirmation

• Vendor reputation

• Customer reviews

Why is analytical testing important?

Independent testing helps verify product identity, purity, molecular integrity, stability, and batch consistency while improving research reproducibility.

Final Thoughts

Mazdutide (IBI362 / LY3305677) continues to attract significant research interest because of its dual GLP-1 receptor and glucagon receptor activity, extended-signaling design, and relevance to metabolic biology. Researchers continue investigating its role in energy homeostasis, glucose regulation, appetite control, lipid metabolism, body-composition pathways, obesity research, and endocrine communication.

When comparing Mazdutide vendors, researchers should prioritize purity verification, third-party analytical testing, Certificate of Analysis availability, mass spectrometry confirmation, vendor reputation, and overall value rather than focusing solely on cost. A structured vendor-comparison process can help identify suppliers capable of meeting rigorous research-quality standards.