Where to Buy Mazdutide: Vendor Comparison & Research Info

Mazdutide, also known as IBI362 and LY3305677, is a synthetic peptide designed to activate both the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). This dual-receptor profile has made Mazdutide an important subject of metabolic research involving energy balance, glucose regulation, lipid metabolism, and body-weight biology.

Mazdutide is structurally related to oxyntomodulin, an endogenous peptide that naturally interacts with both GLP-1 and glucagon pathways. Its molecular design incorporates modifications intended to improve stability and prolong its circulating activity, making it suitable for extended research protocols.

The product is supplied as a lyophilized research peptide and is intended strictly for laboratory research. It is not intended for human or veterinary use.

Mechanism of Action

Mazdutide is being investigated as a dual GLP-1R/GCGR agonist. Activation of GLP-1 receptors is associated with pathways involved in glucose-dependent insulin signaling, appetite regulation, and energy balance, while glucagon receptor activation is involved in hepatic glucose and lipid metabolism and energy expenditure.

Studying both pathways simultaneously allows researchers to examine how combined receptor activation influences metabolic regulation compared with selective GLP-1 receptor agonism.

Molecular Characteristics

• Product Name: Mazdutide

• Synonyms: IBI362, IBI-362, LY3305677

• CAS Number: 2259884-03-0

• Molecular Formula: C₂₁₀H₃₂₂N₄₆O₆₇

• Approximate Molecular Weight: 4,563.1 g/mol

• Receptor Profile: GLP-1R and GCGR dual agonist

• Form: Lyophilized powder

PubChem lists Mazdutide under CAS 2259884-03-0 with the molecular formula C₂₀₇H₃₁₇N₄₅O₆₅ and a calculated molecular weight of 4,476 g/mol, while commercial analytical references report a related molecular specification of C₂₁₀H₃₂₂N₄₆O₆₇ and 4,563.1 g/mol. Because peptide specifications can differ according to molecular form and analytical convention, the batch-specific Certificate of Analysis should be treated as the definitive product specification.

Research Applications

1. Metabolic Signaling Research

Mazdutide provides a research model for examining the interaction between GLP-1 and glucagon signaling. Researchers can investigate how simultaneous activation of these receptors influences energy homeostasis and metabolic pathways.

2. Glucose Regulation

GLP-1 signaling is closely associated with glucose-dependent insulin secretion, while glucagon signaling has important effects on hepatic glucose metabolism. Mazdutide therefore offers a framework for studying the interaction between these endocrine pathways.

3. Body-Composition Research

Researchers are investigating dual GLP-1R/GCGR agonism in relation to changes in body weight, fat metabolism, energy expenditure, and preservation of lean tissue.

4. Lipid and Liver Metabolism

Glucagon receptor activity has an important role in hepatic lipid metabolism. Mazdutide is consequently of interest in experimental research involving hepatic fat metabolism and metabolic liver disorders.

5. Obesity and Metabolic-Disease Models

Mazdutide has progressed through clinical research programs investigating obesity and metabolic disorders. The compound has also been recognized by the IUPHAR/BPS database as an approved drug in China as of 2025, so it should not be described simply as an untested "research chemical."

Structural Design

Mazdutide incorporates structural modifications intended to improve its stability and pharmacokinetic characteristics. Research descriptions identify modifications involving a non-natural amino-acid substitution and a lipid-containing side chain attached through a linker. These features contribute to prolonged exposure compared with native peptide hormones.

The extended molecular design makes Mazdutide particularly relevant to studies examining sustained receptor activation and longer-duration metabolic signaling.

Quality & Analytical Testing

For laboratory research, researchers should evaluate peptide identity, purity, and batch consistency using appropriate analytical documentation.

Depending on the supplier and batch, analytical characterization may include:

• HPLC for purity assessment

• Mass spectrometry for molecular-weight confirmation

• NMR or other structural techniques where applicable

• Batch-specific Certificate of Analysis (CoA)

Published commercial analytical data for Mazdutide demonstrate the type of documentation that can be used to verify molecular identity and purity.

Key Features

• Dual-Receptor Research: Investigates GLP-1R and glucagon receptor signaling simultaneously.

• Metabolic Research: Relevant to glucose, lipid, energy-balance, and body-composition studies.

• Extended-Activity Design: Structural modifications support prolonged peptide exposure.

• Lyophilized Format: Suitable for controlled laboratory research and analytical applications.

• Well-Characterized Compound: Also known as IBI362 and LY3305677.

• Analytical Documentation: Batch-specific purity and identity data should be reviewed before research use.

*Molecular specifications can vary according to the molecular form reported; consult the applicable Certificate of Analysis for the supplied material.

Research-Use Disclaimer

For research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease or medical condition. Researchers should follow applicable laboratory, regulatory, storage, handling, and disposal requirements and rely on current batch-specific documentation for product specifications.