Where to Buy CJC-1295 No DAC: Vendor Comparison & Research Info

CJC-1295 No DAC, also known as Modified GRF (1-29), is a synthetic analog of growth hormone-releasing hormone (GHRH). It consists of 29 amino acids and is designed to provide researchers with a stable model for investigating GHRH receptor activity and growth hormone signaling.

CJC-1295 No DAC differs from CJC-1295 with DAC because it does not contain the Drug Affinity Complex (DAC). As a result, it has a comparatively shorter duration of activity, making it particularly useful for laboratory studies examining transient or pulsatile growth hormone signaling.

The peptide is primarily investigated in research involving the GHRH receptor, pituitary growth hormone secretion, somatotropic-axis activity, and IGF-1-related signaling.

CJC-1295 No DAC Structure

Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: 3,367.9 g/mol
CAS Number: 863288-34-0

Amino Acid Sequence:
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂

CJC-1295 No DAC incorporates several structural modifications designed to improve peptide stability compared with the native GHRH (1-29) sequence. These modifications provide researchers with a defined synthetic model for studying receptor binding, peptide stability, and downstream endocrine signaling.

Mechanism of Research Interest

CJC-1295 No DAC is studied primarily for its interaction with GHRH receptors located on pituitary somatotroph cells. Activation of these receptors is associated with intracellular signaling pathways involved in growth hormone secretion.

Research involving this peptide can examine:

• GHRH receptor activation

• Growth hormone secretion

• Pituitary signaling

• Somatotropic-axis regulation

• IGF-1-related pathways

• Pulsatile hormone signaling

• Peptide-receptor interactions

• Endocrine feedback mechanisms

Its relatively short activity profile makes it particularly relevant to experimental protocols designed to investigate short-duration stimulation and naturally occurring hormone-pulse patterns.

Research Applications

Growth Hormone Research

CJC-1295 No DAC is commonly investigated as a laboratory model for studying growth hormone regulation. Researchers can use it to examine how modified GHRH analogs interact with pituitary receptors and influence downstream endocrine pathways.

Areas of study include:

• Growth hormone release

• Pituitary function

• GHRH signaling

• Hormonal feedback

• IGF-1 signaling

• Somatotropic-axis physiology

Peptide Stability Research

The modified structure of CJC-1295 No DAC also makes it useful for investigating how specific amino acid substitutions influence peptide stability and biological activity.

Research may examine:

• Enzymatic degradation

• Peptide stability

• Structure-activity relationships

• Receptor selectivity

• Molecular interactions

• Synthetic peptide design

Physical Properties

• Appearance: White to off-white lyophilized powder

• Purity: ≥99%

• Form: Lyophilized peptide

• Solubility: Suitable for laboratory reconstitution using compatible aqueous research solutions

• Research Classification: Synthetic GHRH analog

Storage and Handling

Lyophilized CJC-1295 No DAC should be stored according to established peptide laboratory protocols and protected from excessive heat, moisture, and direct light.

For optimal stability:

• Keep the peptide in a controlled environment.

• Minimize exposure to moisture.

• Protect from direct light.

• Avoid unnecessary temperature fluctuations.

• Follow validated laboratory procedures for reconstitution and storage.

• Minimize repeated freeze-thaw cycles where practical.

Key Research Features

• Synthetic Modified GRF (1-29) peptide

• 29-amino-acid GHRH analog

• Investigated for GHRH receptor activity

• Useful for growth hormone signaling research

• Relevant to pulsatile endocrine research

• Studied in IGF-1 and somatotropic-axis models

• Modified structure designed for improved stability

• Supplied as a lyophilized research compound

Research Disclaimer

CJC-1295 No DAC is an investigational research compound intended for qualified laboratory and scientific research. It is not intended for human consumption, therapeutic use, or veterinary applications. Research findings from laboratory and preclinical models should not be interpreted as established evidence of safety or efficacy in humans.