Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.

5-Amino-1MQ Overview

5-amino-1MQ (5-amino-1methylquinolinium) an analogue of methylquinolinium, is a short peptide inhibitor of cytosolic nicotinamide N-methyltransferase (NNMT). The NNMT enzyme has been linked to both obesity and type 2 diabetes and is known to play a role in energy homeostasis within the cell. Inhibiting NNMT leads to significant weight loss, decreased fat mass and fat cell (adipocyte) size, and lower plasma cholesterol and glucose levels. 5-amino-1MQ and other methylquinolinium derivatives are under active investigation as potential treatments for obesity and diabetes. It also appears that inhibition of NNMT can activate stem cells and improve regenerative capacity in skeletal muscle.

5-Amino-1MQ Structure

Molecular Formula: C10H11N2 Molecular Weight: 159.21 g/mol PubChem CID: 950107 CAS Number: 42464-96-0 Synonyms: 5-amino-1-methylquinolinium

5-Amino-1MQ Research

Obesity

Nicotinamide N-methyltransferase is a cytosolic enzyme found in many cells throughout the body, but is most abundant in liver and fat cells. Research in mice shows that high levels of NNMT are associated with decreased levels of the sugar transporter GLUT4. GLUT4, which is primarily in striated muscle (skeletal and cardiac) and fat cells, is heavily linked to blood sugar levels and the development of diabetes. In rodent studies, mice that produce high levels of GLUT4 are insulin sensitive and relatively resistant to the development of type 2 diabetes while mice with low GLUT4 levels demonstrate profound insulin resistance.

In fact, GLUT4 has been linked to basal metabolic rate and the concepts of fast and slow metabolism. Individuals with naturally high levels of GLUT4 have “faster metabolism” than those with low levels of GLUT4 and burn more calories as a result. It is also true that production of the transporter is stimulated by exercise, explaining why exercise can help to combat weight loss, elevated blood sugar levels, and insulin resistance. As it turns out, GLUT4 and NNMT are closely linked to one another and to basal metabolism in mammals [1]. According to Dr. Barbara Kahn of Harvard Medical School, the connection between GLUT4 and NNMT is what first led to the investigation of the latter enzyme as a potential target in the treatment of diabetes and obesity. High levels of NNMT are often found in the fat cells of animals with insulin resistance. Manipulating this gene helps to counteract insulin resistance and thus diabetes. It also has a profound effect on weight and obesity.

Human metabolism, and indeed all animal metabolism is highly efficient, making the most use out of a limited number of calories. Unfortunately, this very efficiency may be the mechanism underlying our penchants for obesity in the setting of excess calorie intake. Reducing the efficiency of human metabolism, causing the body to essentially waste calories, has long been a holy grail of medicine as it works to combat the growing obesity epidemic. NNMT and its interactions with GLUT4 may be the link that scientists have been searching for. [2], [3].

In the most basic sense, NNMT slows how quickly the body utilizes calories thereby leaving them available for storage in fat or glycogen. Decreased NNMT levels decrease the conversion of nicotinic acid (NA) into 1-methylnicotinamide (1-MNA). This process has two effects on metabolism as follows.

So the net result of administering an NNMT blocker like 5-amino-1MQ is an increase in energy burning and a decrease in energy storage. When this is coupled with the fact that decreased NNMT levels also increases GLUT4 transporter expression, you have a recipe for improve glucose clearance from the blood and then direct disposition of that glucose when it is burned. The results are decreased need for insulin, decreased insulin resistance, decreased fat production, and increased energy metabolism. Studies in mice over just 10 days of 5-amino-1MQ administration reveal a 7% reduction in rate and a 30% reduction in fat mass. In addition, blood cholesterol levels in treated mice are equal to those of non-obese mice. Remarkably, these changes occur without any alteration in food consumption [5]. Mice given 5-amino-1MQ show a 7% reduction in body mass over just 10 days, without any changes in food intake, compared to controls:

More recent evidence suggests that the benefit of 5-amino-1MQ may extend beyond its ability to downregulate NNMT and thus increase inefficient metabolism and GLUT4 expression. Research in mice suggests that by boosting GLUT4 expression, 5-amino-1MQ may alter the way fat cells work, leading them to produce an alternative class of lipids that have anti-diabetic and anti-inflammatory effects. This class of lipids, known as PAHSAs (palmitic acid esters of hydroxy-stearic acids), can reduce insulin resistance on their own and reduce inflammation leading to improved risk profiles for events like heart attack and stroke [6]. Those this aspect of 5-amino-1MQ is relatively new, it hints at an extended benefits profile for this already remarkable molecule.

5-Amino-1MQ and Muscle Function

The impact of 5-amino-1MQ on skeletal muscle is multifaceted. Much like in adipose tissue, the presence of 5-amino-1MQ in muscle promotes the production of the GLUT4 receptor and boosts the inefficiency of metabolism leading to increased energy burn. Recent research in mice, however, suggests that inhibiting NNMT in any way, including with 5-amino-1MQ, may actually boost muscle repair by stimulating stem cells.

Research in 24-month-old mice (old for mice) reveals that those treated with an NNMT inhibitor experience substantial stem cell activation in muscle tissue, following injury, compared to controls. These mice exhibit myofibers that are 2-fold larger in cross section and have greater contractile strength. In fact, mice treated with NNMT inhibitors have 70% more contractile force in healed muscle than control mice [7]. The benefits of boosting muscle stem cell production go well beyond simply accelerating rates of repair following injury. Stimulating stem cells could help elderly people maintain their independence for much longer. By improving mobility and reducing the risk of things like falls, NNMT inhibitors could substantially improve quality of life and levels of independent living among older adults.

There is also evidence that increased NNMT expression is a common feature of muscle wasting disorders such as Duchenne Muscular Dystrophy and that reducing NNMT levels may help to alleviate the symptoms of some of these conditions [8]. This, again, is tied in to the ability of NNMT to inhibit stem cell growth and division. By reducing NNMT levels, compounds like 5-amino-1MQ may provide benefit in a variety of muscle-wasting conditions.

The exact effects of NNMT inhibition on muscle function are not fully understood, but another component appears to relate to NAD+ levels. Recall that NNMT inhibition results in increased levels of NAD+. By replenishing NAD+ levels via NNMT inhibition, compounds like 5-amino-1MQ have been shown to improve muscle function, heart pathology, and DMD in animal models. It appears that improvement in mitochondrial function combined with decreases in inflammation and fibrosis, all related to increases in NAD+ levels, are the main drivers of these benefits [9].

A Possible Role for 5-Amino-1MQ in Cognition

NAD+ is a critical compound in brain energy homeostasis. Depletion of NAD+ has been linked to a number of cognitive conditions, but is known to impact communication at the synaptic junction of neurons and at the neuromuscular junction where nerves connect to muscle tissue. Research in mice suggests that decreases in NAD+ levels can reduce synaptic transmission, impair muscle function, and impact overall cognitive function [10]. Though 5-amino-1MQ has not been specifically tested in this setting, there is good reason to believe that the compound will have the same effect on NAD+ levels in the brain as it has elsewhere. This means that it could be used not just as a treatment for cognitive dysfunction, but as a potential nootropic to boost cognitive function in the average individual. Whether this bears out in research remains to be seen, but there is active interest in the potential cognitive benefits of 5-amino-1MQ.

NNMT and Cancer

There is significant research to suggest that NNMT expression is increased in gastric cancers of all types as well as pancreatic cancer, renal cell carcinoma, and bladder cancer. Mice without the NNMT gene so resistance to the development of these cancers, suggesting a causal role for NNMT. Though the research is still in progress, there is some speculation that inhibition NNMT may be a way to both treat and prevent certain types of cancer or, at the very least, reduce how aggressive certain cancer are[8]. It remains to be seen whether 5-amino-1MQ, by reducing NNMT function, will have any effect on the various cancers mentioned.

5-Amino-1MQ Summary

5-amino-1MQ is a small, membrane permeable analogue of naturally occurring methylquinolinium. It has been shown, in animal models to inhibit expression of the enzyme nicotinamide N-methyltransferase. NNMT is an important component of cellular energy metabolism and has been linked heavily to weight control and insulin resistance. Studies show that inhibiting NNMT with 5-amino-1MQ can lead to weight reduction, resistance to diabetes, and improved plasma cholesterol levels. There is also good evidence to show that NNMT inhibition can help to regulate muscle and nerve cell function and there is some hope that compounds like 5-amino-1MQ may play a role in the treatment of conditions like muscular dystrophy and the muscle wasting that results from age. Reductions in levels of NNMT have been linked to reduced aggressiveness in several different varieties of cancer.

Article Author

The above literature was researched, edited and organized by Dr. E. Logan, M.D. Dr. E. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Scientific Journal Author

Barbara B. Kahn is chief of the Division of Endocrinology, Diabetes, and Metabolism at Beth Israel Deaconess Medical Center (BIDMC) and the George Richards Minot Professor of Medicine at Harvard Medical School. She is an internationally recognized scientist in the area of obesity and type 2 diabetes, and her lab investigates the molecular mechanisms underlying these conditions, including the regulation of insulin action, food intake, and energy balance. Kahn received BA and MD degrees from Stanford University and an MS from the University of California at Berkeley. After completing internal medicine training at the UC Davis Medical Center, she began her career in molecular research at the National Institutes of Health. Kahn has received numerous awards including the Outstanding Scientific Achievement Award from the American Diabetes Association; the H. C. Jacobaeus Prize from the Novo Nordisk Foundation and the Karolinska Institutet; the Charles H. Best Lectureship and Award from the University of Toronto; and the Gerald D. Aurbach Award Lecture from the Endocrine Society. Kahn was elected to the Institute of Medicine of the National Academies and is a fellow of the American Association for the Advancement of Science.

Barbara B. Kahn is being referenced as one of the leading scientists involved in the research and development of 5-Amino-1MQ. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Peptide review and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Barbara B. Kahn is listed in [2] and [6] under the referenced citations.

Referenced Citations

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body.  These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease.  Bodily introduction of any kind into humans or animals is strictly forbidden by law.

5-Amino-1MQ is a synthetic small-molecule research compound that has gained significant attention in metabolic biology, cellular energy regulation, and nicotinamide N-methyltransferase (NNMT) research. Unlike peptide-based products, 5-Amino-1MQ is a non-peptidic quinolinium derivative investigated for its ability to inhibit NNMT, an enzyme associated with cellular energy metabolism, adipocyte biology, NAD+ regulation, and metabolic pathways.

As research interest continues to grow, researchers are increasingly comparing 5-Amino-1MQ vendors based on pricing, purity, laboratory testing, Certificates of Analysis (COAs), and supplier transparency.

This 5-Amino-1MQ Vendor Price Comparison Guide helps researchers identify reputable suppliers and compare products based on objective criteria including:

• Product Pricing

• Cost Per Milligram

• Product Purity

• Third-Party Testing

• Certificate of Analysis (COA)

• Vendor Reputation

• Customer Reviews

• Shipping Performance

• Product Availability

• Overall Value

Whether you're searching for the most affordable 5-Amino-1MQ vendor, suppliers with extensive analytical testing, or highly rated research chemical providers, this guide can help streamline your evaluation process.

Explore 5-Amino-1MQ Vendors by Criteria

Most Popular 5-Amino-1MQ Vendors

Explore suppliers frequently chosen by researchers and research chemical buyers.

Highest Reviewed 5-Amino-1MQ Vendors

Compare vendors with strong customer satisfaction and positive marketplace reviews.

Lowest Price 5-Amino-1MQ Vendors

Identify suppliers offering competitive pricing and attractive bulk-purchase options.

Highest Purity 5-Amino-1MQ Vendors

Review suppliers providing detailed purity testing and analytical verification.

Best Value 5-Amino-1MQ Vendors

Compare pricing, testing standards, shipping policies, and customer support to determine overall value.

Fastest Shipping 5-Amino-1MQ Vendors

Evaluate fulfillment speed, order processing times, and delivery performance.

Newly Listed 5-Amino-1MQ Vendors

Discover recently launched suppliers offering 5-Amino-1MQ research products.

What Is 5-Amino-1MQ?

Overview

5-Amino-1MQ (5-Amino-1-Methylquinolinium) is a synthetic small-molecule research compound investigated primarily as an inhibitor of nicotinamide N-methyltransferase (NNMT).

NNMT is an enzyme involved in multiple cellular processes, including:

• Energy metabolism

• NAD+ metabolism

• Adipocyte biology

• Cellular homeostasis

• Metabolic regulation

Researchers utilize 5-Amino-1MQ as a laboratory tool to examine the biological consequences of NNMT inhibition and its interaction with metabolic signaling pathways.

Molecular Characteristics

Chemical Information

Researchers evaluating 5-Amino-1MQ products should review compound-specific documentation and analytical reports.

Chemical Name

5-Amino-1-Methylquinolinium

Common Name

5-Amino-1MQ

Molecular Formula

C10H11N2

Molecular Weight

159.21 g/mol

CAS Number

42464-96-0

PubChem CID

950107

Compound Classification

Synthetic Small-Molecule Research Compound

Research Target

Nicotinamide N-Methyltransferase (NNMT)

Unlike peptide products, 5-Amino-1MQ is a chemically synthesized research compound with distinct molecular and pharmacological characteristics.

Why Vendor Quality Matters

Research outcomes can be significantly influenced by product quality and analytical accuracy.

Not all suppliers follow identical quality-control procedures, and vendor differences may include:

• Purity levels

• Manufacturing consistency

• Batch-to-batch reliability

• Testing methodologies

• Storage requirements

• Documentation transparency

• Packaging standards

A lower-priced supplier may not provide the same level of analytical verification or product consistency as a vendor offering comprehensive testing data.

How We Compare 5-Amino-1MQ Vendors

Third-Party Laboratory Testing

Independent testing is one of the most important quality indicators.

Researchers should prioritize vendors that provide:

• Third-party verification

• Batch-specific testing

• Identity confirmation

• Purity analysis

Certificate of Analysis (COA)

A Certificate of Analysis helps verify product quality and testing standards.

Researchers should review:

• Batch numbers

• Purity percentages

• Analytical methods

• Test dates

• Identity confirmation

Product Purity

Product purity directly impacts research consistency.

Suppliers that disclose detailed purity information and analytical testing procedures typically receive higher rankings.

Cost Per Milligram

Comparing product pricing based solely on container prices can be misleading.

Cost Per Milligram Formula

Product Price ÷ Total Milligrams = Cost Per Milligram

This provides a more accurate comparison of value across multiple vendors.

Customer Reviews

Customer feedback may reveal useful information about:

• Product consistency

• Shipping reliability

• Packaging quality

• Customer service

• Overall purchasing experience

Vendor Reputation

Established suppliers often demonstrate:

• Long-term marketplace presence

• Consistent quality standards

• Transparent laboratory testing

• Reliable customer support

Current Research & Evidence

NNMT Inhibition Research

The primary research interest in 5-Amino-1MQ stems from its activity as an NNMT inhibitor.

Researchers have investigated how restricting NNMT activity influences cellular energy utilization, NAD+ metabolism, and metabolic signaling pathways.

Metabolic Biology Research

Experimental investigations have explored the relationship between NNMT activity and systemic metabolic regulation.

Areas of interest include:

• Energy utilization pathways

• Cellular metabolism

• Nutrient handling

• Metabolic adaptation mechanisms

Adipocyte Biology Research

Research has examined NNMT expression within adipose tissue and how inhibition may influence cellular processes related to fat-cell metabolism.

NAD+ Regulation Research

NNMT is closely associated with NAD+ metabolic pathways.

Researchers have explored how modulation of NNMT activity may influence cellular NAD+ availability and energy homeostasis.

Glucose Metabolism Research

Experimental studies have also examined interactions between NNMT signaling and pathways associated with glucose transport and metabolic regulation.

Key Findings on 5-Amino-1MQ Research

Energy Metabolism

Research suggests that NNMT plays a role in cellular energy balance and metabolic efficiency.

As a result, 5-Amino-1MQ has become a valuable research tool in investigations involving energy utilization pathways.

Metabolic Regulation

Experimental studies indicate that NNMT inhibition may influence several interconnected metabolic networks.

Researchers continue to investigate how these pathways interact within different tissue systems.

Adipose Tissue Research

Research models have examined relationships between NNMT expression, adipocyte biology, and metabolic activity.

Skeletal Muscle Research

Experimental investigations have explored how NNMT activity influences muscle-associated biological pathways and cellular energy regulation.

Stem Cell Biology

Some research has examined relationships between NNMT inhibition and mechanisms involved in cellular regeneration and stem-cell activity.

NAD+ Associated Pathways

Researchers remain interested in how NNMT inhibition may impact biological systems connected to NAD+ metabolism and mitochondrial function.

Research Limitations

Although 5-Amino-1MQ has produced intriguing findings in preclinical research, many investigations remain at the laboratory and animal-study stage.

Results observed in experimental systems should not be interpreted as evidence of clinical efficacy, safety, or therapeutic benefit in humans.

Product Quality & Analytical Testing

Why Analytical Testing Matters

Quality testing helps verify:

• Chemical identity

• Product purity

• Stability

• Batch consistency

• Manufacturing reliability

Common Testing Methods

High-Performance Liquid Chromatography (HPLC)

Used to assess purity and identify impurities.

Mass Spectrometry (MS)

Used to verify molecular weight and compound identity.

Nuclear Magnetic Resonance (NMR)

Used to characterize structural integrity.

Identity Verification

Confirms the product matches the expected molecular composition.

Stability Testing

Evaluates compound integrity under specified storage conditions.

Batch Consistency Testing

Measures variation between production lots.

Understanding 5-Amino-1MQ Pricing

Several factors can influence pricing among suppliers.

Product Purity

Products with higher documented purity often command premium prices.

Laboratory Testing

Comprehensive analytical verification increases supplier costs but improves transparency.

Manufacturing Standards

Higher manufacturing standards generally require additional quality-control procedures.

Packaging and Storage

Protective packaging and storage protocols may affect overall product pricing.

Brand Reputation

Established suppliers commonly charge more for trusted quality and documented consistency.

5-Amino-1MQ Vendor Evaluation Checklist

Quality Verification

✅ Third-party testing available

✅ Certificate of Analysis provided

✅ Purity information disclosed

✅ Identity verification documented

✅ Batch-specific testing

Vendor Reliability

✅ Positive customer reviews

✅ Transparent supplier information

✅ Responsive customer support

✅ Consistent inventory availability

Ordering Experience

✅ Secure checkout process

✅ Shipping tracking available

✅ Clear refund policy

✅ Reliable order fulfillment

Warning Signs When Comparing Vendors

Testing Red Flags

❌ No third-party testing

❌ Missing COAs

❌ Unverified purity claims

❌ Outdated laboratory reports

Transparency Concerns

❌ Hidden product specifications

❌ No batch numbers

❌ Limited analytical documentation

❌ Missing business contact information

Customer Service Issues

❌ Negative customer reviews

❌ Poor communication

❌ Frequent stock shortages

❌ Unclear shipping policies

How to Choose the Best 5-Amino-1MQ Vendor

Prioritize Testing Transparency

Choose suppliers that provide comprehensive analytical testing and batch-specific COAs.

Compare Overall Value

Balance product cost against purity, testing standards, and supplier reliability.

Review Documentation

Verify analytical reports before purchasing.

Consider Vendor Reputation

Long-standing suppliers with positive customer feedback often provide more consistent experiences.

Evaluate Research Requirements

Select vendors that match your laboratory's specific quality, shipping, and documentation requirements.

Frequently Asked Questions

What is 5-Amino-1MQ?

5-Amino-1MQ is a synthetic small-molecule research compound commonly investigated as an inhibitor of nicotinamide N-methyltransferase (NNMT).

Is 5-Amino-1MQ a peptide?

No. 5-Amino-1MQ is not a peptide. It is a synthetic small-molecule research compound.

Why compare 5-Amino-1MQ vendors?

Product quality, analytical testing, purity standards, pricing, and supplier reliability can vary significantly between vendors.

What should I review before purchasing?

Researchers should evaluate:

• Certificate of Analysis

• Product purity

• Testing methodology

• Batch information

• Vendor reputation

• Customer reviews

Why is third-party testing important?

Independent laboratory testing helps verify product identity, purity, and quality.

Is the cheapest vendor always the best choice?

Not necessarily. Product consistency, testing documentation, and supplier reliability are often more important considerations.

How often should vendor comparisons be updated?

Because pricing, inventory, and testing documentation frequently change, comparisons should be reviewed and updated regularly.

Final Thoughts

As interest in NNMT research continues to expand, 5-Amino-1MQ remains a frequently discussed research compound in studies involving metabolic regulation, adipocyte biology, energy metabolism, NAD+ pathways, and cellular signaling. Researchers should prioritize vendors that provide strong analytical documentation, independent testing, transparent purity reporting, and reliable customer support.

By comparing suppliers using objective criteria such as testing standards, product purity, pricing, and reputation, researchers can identify the vendors that best align with their laboratory and research requirements.