Where to Buy Acipotide: Vendor Comparison & Research Info

Adipotide is an experimental peptidomimetic compound investigated primarily in preclinical research involving white adipose tissue, vascular targeting, prohibitin (PHB) signaling, and metabolic biology. Research has examined how Adipotide can target blood vessels associated with white adipose tissue and influence cellular pathways involved in adipose-tissue regulation. Studies in animal models have reported changes in adipose tissue and metabolic parameters, but these findings remain experimental and should not be interpreted as evidence of an approved human therapy.

Overview

Adipotide is a chimeric peptide consisting of a targeting component and a pro-apoptotic sequence. Its research interest comes from its ability to recognize prohibitin-associated targets on the surface of vascular endothelial cells within white adipose tissue. The targeting sequence is designed to direct the compound toward specific vascular structures, while the attached pro-apoptotic component has been studied for its effects on targeted cells.

Experimental research has primarily used animal models to investigate adipose-tissue targeting, vascular biology, apoptosis, and metabolic changes. These studies provide a framework for examining how targeted peptide approaches may interact with specific tissue-associated vascular systems.

Molecular Characteristics

According to PubChem, Adipotide has the following chemical characteristics:

• Chemical Name: Adipotide

• Synonyms: Adipotide, HKPao, EX-A6186

• Molecular Formula: C₁₁₁H₂₀₆N₃₆O₂₈S₂

• Molecular Weight: 2557.2 g/mol

• CAS Number: 859216-15-2

• Sequence: CKGGRAKDCGGKLAKLAKKLAKLAK

The compound contains both L- and D-amino-acid residues, a structural characteristic relevant to its design and research properties.

Research Applications

Adipotide has been investigated in several areas of experimental research, including:

• Adipose-Tissue Biology: Studying cellular and vascular mechanisms associated with white adipose tissue.

• Vascular Targeting: Investigating peptide-directed targeting of blood vessels associated with adipose tissue.

• Prohibitin Research: Examining PHB-associated signaling at the vascular endothelial cell surface.

• Apoptosis Research: Studying targeted cellular responses to pro-apoptotic peptide sequences.

• Metabolic Research: Exploring relationships between adipose tissue, insulin sensitivity, and metabolic regulation.

• Targeted Peptide Delivery: Evaluating strategies for directing biologically active peptide sequences toward specific tissues.

Mechanism of Research Interest

The central research concept behind Adipotide involves ligand-directed targeting of prohibitin-associated structures on adipose-tissue vasculature. Following targeting, the pro-apoptotic portion of the molecule has been investigated for its ability to affect targeted vascular cells. This mechanism provides researchers with a model for studying tissue-selective peptide targeting and vascular-cell apoptosis.

Research into prohibitin is also relevant because PHB has been identified on vascular endothelial cells and adipocytes and has been associated with fatty-acid transport within adipose tissue.

Preclinical Research

One notable study investigated Adipotide in obese nonhuman primates. Researchers reported targeted effects involving blood vessels within white adipose tissue, along with reductions in white adipose tissue and changes in insulin resistance. The study also reported reversible changes in renal proximal-tubule function at experimentally determined doses, highlighting the importance of safety evaluation in subsequent research.

These findings represent preclinical research observations and should not be interpreted as establishing safety, efficacy, or an approved medical application in humans.

Product Quality & Analytical Testing

Research-grade Adipotide should be evaluated using appropriate analytical methods to establish identity, purity, and batch consistency. Depending on the research application, quality assessment may include:

• HPLC: Evaluation of peptide purity and related impurities.

• Mass Spectrometry: Confirmation of molecular mass and identity.

• Peptide Mapping: Assessment of sequence-related characteristics.

• Batch Testing: Comparison of quality between production lots.

• Stability Analysis: Monitoring peptide integrity under defined storage conditions.

Research Use Only: Adipotide is an investigational research compound. It is not an approved medication and should not be presented as a treatment for obesity, weight loss, metabolic disease, or any other medical condition. Product information, analytical documentation, and independent laboratory results should be reviewed when evaluating research-grade material.