Where to Buy Lioresal: Vendor Comparison & Research Info

Lioresal (Baclofen) is a centrally acting skeletal muscle relaxant and GABA-B receptor agonist studied in neurology, neuropharmacology, and musculoskeletal research. It provides a useful research model for investigating inhibitory neurotransmission, spinal reflex activity, muscle tone, and mechanisms involved in spasticity.

Overview

Baclofen is a structural analogue of gamma-aminobutyric acid (GABA) that primarily acts on GABA-B receptors in the central nervous system. Activation of these receptors can reduce excitatory neurotransmitter release and alter neuronal activity involved in muscle contraction.

Because of its defined mechanism, baclofen is frequently investigated in experimental models examining motor control, spinal circuitry, and abnormal muscle tone.

Molecular Characteristics

• Active Ingredient: Baclofen

• Chemical Class: GABA-B receptor agonist

• Molecular Formula: C₁₀H₁₂ClNO₂

• Molecular Weight: 213.66 g/mol

• CAS Number: 1134-47-0

• Research Category: Centrally acting muscle relaxant / neuromuscular research compound

Research Applications

Baclofen can be investigated in several areas, including:

• GABA-B receptor signaling

• Spinal motor-neuron activity

• Skeletal muscle tone regulation

• Neuromuscular physiology

• Neuropharmacology

• Spasticity research

• Inhibitory neurotransmission

• Motor-control mechanisms

• Pharmacokinetic and pharmacodynamic studies

Mechanism of Action

Baclofen acts primarily as an agonist at GABA-B receptors, which are metabotropic receptors involved in inhibitory neurotransmission.

Activation of these receptors can reduce neuronal excitability through modulation of calcium and potassium ion channels and suppression of excitatory neurotransmitter release. This makes baclofen particularly useful for studying the neural regulation of muscle tone and spinal reflexes.

Key Mechanistic Features

GABA-B Receptor Activation:
Baclofen provides a model for examining GABA-B-mediated inhibitory signaling.

Reduced Excitatory Transmission:
Research can investigate how GABA-B activation influences the release of excitatory neurotransmitters within neural circuits.

Spinal Reflex Modulation:
Experimental models can assess changes in reflex pathways involved in skeletal muscle contraction.

Motor-Neuron Regulation:
Baclofen can be used to study the relationship between inhibitory neural signaling and motor output.

Primary Research Areas

1. Neuromuscular Research

Baclofen is studied to understand how central inhibitory pathways regulate skeletal muscle activity and muscle tone.

2. Spinal Circuit Research

Researchers investigate GABA-B signaling within spinal networks and its relationship to motor-neuron excitability and reflex responses.

3. Neuropharmacology

Its selective activity at GABA-B receptors makes baclofen a useful compound for investigating inhibitory neurotransmission and receptor-mediated signaling.

4. Muscle-Tone Research

Experimental models can examine the mechanisms through which altered central nervous system activity influences excessive or abnormal muscle contraction.

5. Pharmacological Research

Baclofen may be investigated in studies of receptor pharmacology, pharmacokinetics, metabolism, and drug-interaction mechanisms.

Analytical Testing

Research-grade baclofen formulations may be evaluated using:

• High-Performance Liquid Chromatography (HPLC)

• Liquid Chromatography–Mass Spectrometry (LC-MS)

• Identity testing

• Purity and assay determination

• Stability analysis

• Dissolution testing

• Content uniformity assessment

Analytical characterization helps support compound identity, consistency, and reproducibility in controlled research environments.

Storage & Handling

Lioresal should be stored and handled according to the applicable product documentation and laboratory safety requirements. Researchers should consult the relevant Certificate of Analysis and formulation specifications before experimental use.

Safety & Research Disclaimer

Baclofen is a pharmacologically active central nervous system compound capable of altering inhibitory neurotransmission and motor function. Research should be conducted by qualified personnel using appropriate laboratory and institutional controls.

Lioresal (Baclofen) is intended for legitimate scientific and research applications only and is not intended for self-administration or unsupervised therapeutic use.

Lioresal (Baclofen) is a centrally acting skeletal muscle relaxant and GABA-B receptor agonist extensively investigated in neurology, neuropharmacology, spinal reflex research, neuromuscular physiology, motor-control biology, and inhibitory neurotransmission studies.

As a structural analogue of gamma-aminobutyric acid (GABA), Baclofen provides researchers with a valuable model for examining how GABA-B receptor activation influences neuronal excitability, spinal motor circuits, skeletal muscle tone, and the regulation of inhibitory signaling pathways within the central nervous system.

This Lioresal Vendor Price Comparison Guide helps researchers evaluate suppliers using objective criteria including:

• Product Pricing

• Cost Per Tablet

• Cost Per Milligram

• Active Ingredient Verification

• Product Purity

• Third-Party Testing

• Certificate of Analysis (COA)

• Vendor Reputation

• Customer Reviews

• Shipping Performance

• Product Availability

• Overall Value

Whether you're searching for the lowest-priced Baclofen supplier, the highest-purity formulation, or vendors offering extensive analytical verification, this guide provides a structured framework for supplier evaluation.

Explore Lioresal Vendors by Criteria

Most Popular Lioresal Vendors

Compare suppliers frequently selected by neurology and neuropharmacology researchers.

Highest Reviewed Vendors

Discover vendors with strong customer satisfaction and established supplier reputations.

Lowest Price Vendors

Identify suppliers offering competitive pricing and favorable cost-per-milligram value.

Highest Purity Vendors

Review suppliers providing transparent analytical testing and purity verification.

Best Value Vendors

Compare testing standards, documentation quality, product consistency, pricing, and customer support.

Fastest Shipping Vendors

Evaluate fulfillment performance, packaging quality, and delivery reliability.

Newly Listed Vendors

Explore recently added suppliers offering Baclofen research formulations.

What Is Lioresal?

Overview

Lioresal contains:

• Baclofen

• GABA-B Receptor Agonist

• Centrally Acting Muscle Relaxant

• Neuropharmacology Research Compound

Researchers investigate Baclofen because of its relationship with:

• GABA-B receptor signaling

• Inhibitory neurotransmission

• Spinal reflex activity

• Motor-neuron regulation

• Muscle-tone control

• Neuromuscular physiology

• Neuropharmacology

• Central nervous system signaling

Its highly selective activity at GABA-B receptors makes it one of the most important compounds in inhibitory neurotransmission research.

Molecular Characteristics

Compound Information

Researchers evaluating Lioresal products should carefully review supplier specifications and analytical documentation.

Active Ingredient

Baclofen

Chemical Class

GABA-B Receptor Agonist

Molecular Formula

C₁₀H₁₂ClNO₂

Molecular Weight

213.66 g/mol

CAS Number

1134-47-0

Research Category

Neuromuscular & Neuropharmacology Research

Classification

Centrally Acting Skeletal Muscle Relaxant

What Makes Lioresal Different?

The defining characteristic of Baclofen is its selective activation of GABA-B receptors.

GABA-B Research Utility

Researchers investigate:

• Receptor activation

• Inhibitory neurotransmission

• Synaptic regulation

• Neuronal adaptation

• Signal-transduction pathways

Central Nervous System Research

Scientists frequently study:

• Neuronal excitability

• Spinal signaling

• Motor control systems

• Reflex regulation

• Neural communication

Muscle-Tone Research Applications

Researchers examine:

• Motor-neuron activity

• Skeletal muscle signaling

• Reflex responsiveness

• Neuromuscular adaptation

• Physiological regulation

Why Researchers Study Lioresal

Baclofen remains widely investigated because of its relationship with:

• GABA-B receptor biology

• Inhibitory signaling pathways

• Motor-neuron activity

• Spinal circuitry

• Skeletal muscle tone

• Neuromuscular communication

• Neuropharmacology

• Motor-control physiology

These continue to be important areas of neuroscience and pharmacology research.

Mechanism of Action Research

GABA-B Receptor Activation

The primary scientific interest surrounding Baclofen involves activation of GABA-B receptors.

Researchers investigate pathways involving:

• GABA-B-mediated signaling

• Synaptic communication

• Neuronal inhibition

• Neurotransmitter regulation

• Neural adaptation

This remains the central focus of Baclofen research.

Reduced Excitatory Transmission Research

Researchers frequently examine:

• Excitatory neurotransmitter release

• Presynaptic signaling

• Neural communication

• Cellular responsiveness

• Network regulation

Lioresal & Neuromuscular Research

Skeletal Muscle Tone Research

Researchers investigate pathways involving:

• Muscle-tone regulation

• Motor-neuron responsiveness

• Neuromuscular communication

• Physiological adaptation

• Movement control

This remains one of the most common applications of Baclofen research.

Neuromuscular Physiology Research

Scientists continue studying:

• Motor-system signaling

• Neural-muscular communication

• Functional adaptation

• Regulatory mechanisms

• Physiological coordination

Muscle-Control Research

Studies frequently investigate:

• Movement regulation

• Motor-neuron output

• Neurological communication

• Muscular responsiveness

• Biological adaptation

Lioresal & Spinal Circuit Research

Spinal Reflex Research

Researchers investigate pathways involving:

• Reflex circuitry

• Motor-neuron signaling

• Neural integration

• Spinal communication

• Physiological regulation

Motor-Neuron Activity Research

Scientists continue studying:

• Spinal signaling networks

• Neuronal communication

• Cellular adaptation

• Functional responsiveness

• Neurophysiological pathways

Neural Circuitry Research

Research frequently evaluates:

• Network signaling

• Synaptic interactions

• Regulatory pathways

• Communication systems

• Physiological adaptation

Lioresal & Neuropharmacology Research

Receptor Pharmacology Research

Researchers investigate:

• GABA-B receptor activity

• Ligand-receptor interactions

• Receptor responsiveness

• Signal modulation

• Cellular communication

Inhibitory Neurotransmission Research

Studies frequently examine:

• Inhibitory signaling pathways

• Neuronal regulation

• Synaptic communication

• Neural adaptation

• Central nervous system physiology

Signal-Transduction Research

Scientists continue studying:

• Cellular signaling networks

• Receptor-mediated responses

• Communication pathways

• Molecular adaptation

• Biological regulation

Lioresal & Spasticity Research

Motor Dysfunction Research

Researchers investigate pathways involving:

• Altered muscle tone

• Motor-neuron signaling

• Skeletal muscle physiology

• Neurological adaptation

• Reflex modulation

Muscle-Contraction Research

Scientists frequently examine:

• Contraction signaling

• Neuromuscular communication

• Regulatory mechanisms

• Physiological responsiveness

• Functional adaptation

Lioresal & Inhibitory Signaling Research

Synaptic Regulation Research

Researchers investigate:

• Neurotransmitter release

• Synaptic communication

• Neuronal inhibition

• Regulatory pathways

• Signal integration

Ion Channel Research

Studies frequently evaluate:

• Calcium-channel modulation

• Potassium-channel activity

• Cellular signaling

• Neuronal responsiveness

• Physiological regulation

Lioresal & Pharmacological Research

Pharmacokinetic Research

Researchers investigate:

• Absorption characteristics

• Distribution pathways

• Metabolic transformation

• Elimination mechanisms

• Exposure-response relationships

Pharmacodynamic Research

Scientists continue studying:

• Receptor occupancy

• Signal modulation

• Biological responsiveness

• Dose-response relationships

• Physiological adaptation

Drug Interaction Research

Research frequently examines:

• Receptor-based interactions

• Metabolic pathways

• Pharmacological modulation

• Cellular communication

• Biological responses

Why Researchers Compare Lioresal Vendors

Research reproducibility depends heavily on material quality and manufacturing consistency.

Differences among suppliers may include:

• Baclofen purity

• Active ingredient concentration

• Analytical verification

• Stability testing

• Identity confirmation

• Manufacturing standards

• Batch consistency

• Documentation quality

Careful supplier evaluation helps improve consistency across laboratory studies.

How We Compare Lioresal Vendors

Third-Party Laboratory Testing

Researchers should prioritize suppliers offering:

✅ Third-party testing

✅ Identity verification

✅ Purity confirmation

✅ Batch-specific reports

✅ Analytical documentation

Certificate of Analysis (COA)

A quality COA should include:

• Batch number

• Testing date

• Identity verification

• Purity confirmation

• Analytical methodology

Active Ingredient Verification

Researchers should verify:

• Baclofen identity

• Purity percentage

• Product consistency

• Stability profile

• Analytical validation

Cost Per Milligram

Comparing package prices alone may not accurately reflect value.

Cost Per Milligram Formula

Product Price ÷ Total Milligrams = Cost Per Milligram

Cost Per Tablet Formula

Product Price ÷ Total Tablets = Cost Per Tablet

These metrics standardize supplier comparisons.

Customer Reviews

Customer experiences often provide insight regarding:

• Product consistency

• Packaging quality

• Shipping reliability

• Customer support

• Overall purchasing experience

Vendor Reputation

Established suppliers often demonstrate:

• Transparent testing procedures

• Reliable quality-control systems

• Positive customer feedback

• Consistent inventory availability

Quality & Analytical Testing

Why Testing Matters

Research-grade Lioresal should undergo testing to verify:

• Identity

• Purity

• Potency

• Stability

• Batch consistency

Common Testing Methods

High-Performance Liquid Chromatography (HPLC)

Used to assess purity and verify active-compound concentration.

Liquid Chromatography-Mass Spectrometry (LC-MS)

Used to confirm molecular identity and composition.

Identity Testing

Confirms Baclofen authenticity.

Purity & Assay Determination

Measures active-ingredient concentration and impurity levels.

Stability Analysis

Evaluates long-term formulation integrity.

Dissolution Testing

Assesses formulation consistency and release characteristics.

Content Uniformity Assessment

Measures consistency between tablets and production batches.

Storage & Handling

Researchers should follow validated laboratory procedures.

Best practices include:

✅ Store according to supplier recommendations

✅ Protect from excessive heat

✅ Protect from moisture

✅ Protect from direct sunlight

✅ Maintain original packaging

✅ Keep containers sealed when not in use

✅ Inspect materials before laboratory use

✅ Maintain laboratory documentation

Proper storage helps preserve stability and analytical integrity.

Understanding Lioresal Pricing

Several factors influence supplier pricing.

Product Purity

Higher-purity formulations generally command premium pricing.

Manufacturing Standards

Advanced pharmaceutical manufacturing and quality-control procedures contribute to production costs.

Analytical Verification

Comprehensive testing programs improve transparency while increasing quality-assurance expenses.

Stability Validation

Additional stability studies often increase product value.

Vendor Reputation

Established suppliers frequently command higher pricing because of documented testing programs and rigorous quality-control systems.

Lioresal Vendor Evaluation Checklist

Quality Verification

✅ Third-party testing available

✅ Certificate of Analysis provided

✅ Identity verification documented

✅ Purity testing available

✅ Stability testing available

✅ Assay verification available

✅ Batch-specific reports available

Vendor Reliability

✅ Positive customer reviews

✅ Transparent company information

✅ Responsive customer support

✅ Reliable inventory availability

Purchasing Experience

✅ Secure checkout process

✅ Shipment tracking available

✅ Clear return policies

✅ Reliable order fulfillment

Frequently Asked Questions

What is Lioresal?

Lioresal is a pharmaceutical formulation containing Baclofen, a centrally acting skeletal muscle relaxant and GABA-B receptor agonist.

What is Lioresal used for in research?

Researchers investigate Baclofen in studies involving GABA-B receptor signaling, inhibitory neurotransmission, spinal reflex activity, motor-neuron regulation, neuromuscular physiology, neuropharmacology, and muscle-tone research.

Why is Baclofen important in neuroscience research?

Its selective activation of GABA-B receptors provides a useful model for studying inhibitory signaling pathways, neuronal excitability, synaptic regulation, and motor-control mechanisms.

What should researchers review before purchasing?

Researchers should evaluate:

• Certificate of Analysis (COA)

• HPLC verification

• LC-MS confirmation

• Purity analysis

• Assay determination

• Stability testing

• Vendor reputation

Why is analytical testing important?

Independent testing helps verify identity, purity, potency, stability, dissolution characteristics, and batch consistency while improving research reproducibility.

Is Lioresal a peptide?

No. Lioresal contains Baclofen, a synthetic GABA-B receptor agonist and centrally acting muscle relaxant rather than a peptide. However, it is often offered alongside peptides and other research compounds by specialized research suppliers.

Final Thoughts

Lioresal (Baclofen) remains one of the most important compounds in GABA-B receptor research, inhibitory neurotransmission studies, neuromuscular physiology, spinal reflex biology, motor-neuron regulation, neuropharmacology, and muscle-tone investigations. Its well-characterized mechanism of action provides researchers with a valuable model for understanding central nervous system regulation of movement and inhibitory neural signaling.

When comparing Lioresal vendors, researchers should prioritize purity verification, third-party analytical testing, Certificate of Analysis availability, HPLC validation, LC-MS confirmation, assay determination, stability testing, supplier reputation, and overall value rather than focusing exclusively on price. A structured vendor-comparison process can help identify suppliers capable of maintaining rigorous research-quality standards.