Where to Buy Lioresal: Vendor Comparison & Research Info

Lioresal (Baclofen) is a centrally acting skeletal muscle relaxant and GABA-B receptor agonist studied in neurology, neuropharmacology, and musculoskeletal research. It provides a useful research model for investigating inhibitory neurotransmission, spinal reflex activity, muscle tone, and mechanisms involved in spasticity.

Overview

Baclofen is a structural analogue of gamma-aminobutyric acid (GABA) that primarily acts on GABA-B receptors in the central nervous system. Activation of these receptors can reduce excitatory neurotransmitter release and alter neuronal activity involved in muscle contraction.

Because of its defined mechanism, baclofen is frequently investigated in experimental models examining motor control, spinal circuitry, and abnormal muscle tone.

Molecular Characteristics

• Active Ingredient: Baclofen

• Chemical Class: GABA-B receptor agonist

• Molecular Formula: C₁₀H₁₂ClNO₂

• Molecular Weight: 213.66 g/mol

• CAS Number: 1134-47-0

• Research Category: Centrally acting muscle relaxant / neuromuscular research compound

Research Applications

Baclofen can be investigated in several areas, including:

• GABA-B receptor signaling

• Spinal motor-neuron activity

• Skeletal muscle tone regulation

• Neuromuscular physiology

• Neuropharmacology

• Spasticity research

• Inhibitory neurotransmission

• Motor-control mechanisms

• Pharmacokinetic and pharmacodynamic studies

Mechanism of Action

Baclofen acts primarily as an agonist at GABA-B receptors, which are metabotropic receptors involved in inhibitory neurotransmission.

Activation of these receptors can reduce neuronal excitability through modulation of calcium and potassium ion channels and suppression of excitatory neurotransmitter release. This makes baclofen particularly useful for studying the neural regulation of muscle tone and spinal reflexes.

Key Mechanistic Features

GABA-B Receptor Activation:
Baclofen provides a model for examining GABA-B-mediated inhibitory signaling.

Reduced Excitatory Transmission:
Research can investigate how GABA-B activation influences the release of excitatory neurotransmitters within neural circuits.

Spinal Reflex Modulation:
Experimental models can assess changes in reflex pathways involved in skeletal muscle contraction.

Motor-Neuron Regulation:
Baclofen can be used to study the relationship between inhibitory neural signaling and motor output.

Primary Research Areas

1. Neuromuscular Research

Baclofen is studied to understand how central inhibitory pathways regulate skeletal muscle activity and muscle tone.

2. Spinal Circuit Research

Researchers investigate GABA-B signaling within spinal networks and its relationship to motor-neuron excitability and reflex responses.

3. Neuropharmacology

Its selective activity at GABA-B receptors makes baclofen a useful compound for investigating inhibitory neurotransmission and receptor-mediated signaling.

4. Muscle-Tone Research

Experimental models can examine the mechanisms through which altered central nervous system activity influences excessive or abnormal muscle contraction.

5. Pharmacological Research

Baclofen may be investigated in studies of receptor pharmacology, pharmacokinetics, metabolism, and drug-interaction mechanisms.

Analytical Testing

Research-grade baclofen formulations may be evaluated using:

• High-Performance Liquid Chromatography (HPLC)

• Liquid Chromatography–Mass Spectrometry (LC-MS)

• Identity testing

• Purity and assay determination

• Stability analysis

• Dissolution testing

• Content uniformity assessment

Analytical characterization helps support compound identity, consistency, and reproducibility in controlled research environments.

Storage & Handling

Lioresal should be stored and handled according to the applicable product documentation and laboratory safety requirements. Researchers should consult the relevant Certificate of Analysis and formulation specifications before experimental use.

Safety & Research Disclaimer

Baclofen is a pharmacologically active central nervous system compound capable of altering inhibitory neurotransmission and motor function. Research should be conducted by qualified personnel using appropriate laboratory and institutional controls.

Lioresal (Baclofen) is intended for legitimate scientific and research applications only and is not intended for self-administration or unsupervised therapeutic use.